Prostate - Carcinosarcoma

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Prostate

Other carcinomas

Carcinosarcoma

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 22 March 2012, last major update March 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Also known as sarcomatoid carcinoma, metaplastic carcinoma, spindle-cell carcinoma, and malignant mixed mesodermal tumour
● Rare (<30 patients)
● May represent sarcomatoid transformation of prior adenocarcinoma or be related to radiotherapy or hormonal therapy
● Aggressive clinical course (Am J Surg Pathol 2006;30:1316)

Micro description
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● Biphasic tumor with adenocarcinoma and recognizable sarcoma components (chondrosarcoma, rhabdomyosarcoma, angiosarcoma, osteosarcoma, leiomyosarcoma)

Micro images
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Various images

Positive stains
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● Epithelial component is cytokeratin+, PSA- and PAP+ (Am J Clin Pathol 1989;92:131)

Negative stains
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● Sarcoma component negative for PSA, EMA, keratin

Differential diagnosis
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● Primary prostatic sarcoma, benign spindle cell proliferations such as inflammatory myofibroblastic tumor (pseudosarcomatous fibromyxoid tumor) and postoperative spindle cell nodule can be confused with the mesenchymal component of sarcomatoid carcinoma; note that in recurrent tumors, the mesenchymal component usually overgrows the epithelial component and so a pure sarcomatous pattern in the setting of pretreated adenocarcinoma should be assumed to represent sarcomatoid carcinoma

References
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● Am J Surg Pathol 1993;17:342

End of Prostate > Other carcinomas > Carcinosarcoma

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