Prostate
Adenocarcinoma
Sarcomatoid carcinoma


Topic Completed: 1 March 2012

Revised: 19 January 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed search: prostate sarcomatoid carcinoma

Komal Arora, M.D.
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Cite this page: Arora K. Sarcomatoid carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/prostatecarcinosarcoma.html. Accessed February 27th, 2020.
Definition / general
  • Also known as sarcomatoid carcinoma, metaplastic carcinoma, spindle-cell carcinoma, and malignant mixed mesodermal tumour
  • Rare (< 30 patients)
  • May represent sarcomatoid transformation of prior adenocarcinoma or be related to radiotherapy or hormonal therapy
  • Aggressive clinical course (Am J Surg Pathol 2006;30:1316)
Microscopic (histologic) description
  • Biphasic tumor with adenocarcinoma and recognizable sarcoma components (chondrosarcoma, rhabdomyosarcoma, angiosarcoma, osteosarcoma, leiomyosarcoma)
Microscopic (histologic) images

Contributed by Kenneth Iczkowski, M.D.
Missing Image

Fig. 3: Carcinosarcoma -
The epithelial component
as well as stromal component
are overtly malignant

Positive stains
Negative stains
Differential diagnosis
  • Primary prostatic sarcoma, benign spindle cell proliferations such as inflammatory myofibroblastic tumor (pseudosarcomatous fibromyxoid tumor) and postoperative spindle cell nodule can be confused with the mesenchymal component of sarcomatoid carcinoma; note that in recurrent tumors, the mesenchymal component usually overgrows the epithelial component and so a pure sarcomatous pattern in the setting of pretreated adenocarcinoma should be assumed to represent sarcomatoid carcinoma
Additional references
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