Other carcinomas
Clear cell adenocarcinoma

Topic Completed: 1 March 2012

Revised: 27 February 2019

Copyright: 2003-2019,, Inc.

PubMed search: prostatic clear cell adenocarcinoma

Komal Arora, M.D.
Page views in 2018: 1,054
Page views in 2019 to date: 970
Cite this page: Arora K. Clear cell adenocarcinoma. website. Accessed November 18th, 2019.
Definition / general
  • Extremely rare in men in prostate
  • More common in urethra or bladder
Case reports
Microscopic (histologic) description
  • Tubulocystic and papillary glands lined by glycogen-rich, cuboidal or hobnail cells with clear to eosinophilic cytoplasm
  • Enlarged nuclei with mild pleomorphism and prominent nucleoli
  • May have prominent vasculature, inflammatory infiltrate, hyaline globules, psammoma bodies
  • Resembles ovarian neoplasm
Microscopic (histologic) images

Case of the Week #76

Hyaline globules

Psammoma bodies

Positive stains
  • Pan-keratin, low molecular weight keratin, EMA; focal high molecular weight keratin
Negative stains
  • PSA, PAP
Differential diagnosis
  • Urothelial carcinoma: clear cell variant
  • Renal cell carcinoma: metastatic; history of renal primary
  • Nephrogenic adenoma: tubules composed of single layer of cuboidal or flattened cells with clear to eosinophilic cytoplasm, round nuclei with fine chromatin
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