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Other carcinomas

Clear cell adenocarcinoma

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 16 December 2014, last major update March 2012
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.


● Extremely rare in men in prostate
● More common in urethra or bladder

Case reports

● 16 year old boy from Uruguay with tumor of prostatic utricle (Ann Diagn Pathol 2005;9:153)
● 47 year old man with elevated serum CA125, normal serum PSA, metastasis to testis (Am J Surg Pathol 2000;24:1433)
● 49 year old man with inguinal mass (Case of the Week #76)
● 73 year old man with organ confined disease resembling renal cell carcinoma (Am J Surg Pathol 2003;27:407)

Micro description

● Tubulocystic and papillary glands lined by glycogen-rich, cuboidal or hobnail cells with clear to eosinophilic cytoplasm
● Enlarged nuclei with mild pleomorphism and prominent nucleoli
● May have prominent vasculature, inflammatory infiltrate, hyaline globules, psammoma bodies
● Resembles ovarian neoplasm

Micro images



Case of the Week

Hyaline globules

Psammoma bodies

Positive stains

● Pan-keratin, low molecular weight keratin, EMA; focal high molecular weight keratin

Negative stains


Differential diagnosis

Urothelial carcinoma: clear cell variant
Renal cell carcinoma: metastatic; history of renal primary
Nephrogenic adenoma: tubules composed of single layer of cuboidal or flattened cells with clear to eosinophilic cytoplasm, round nuclei with fine chromatin

End of Prostate > Other carcinomas > Clear cell adenocarcinoma

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