Microscopic mimics of prostatic carcinoma
Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 22 May 2014, last major update May 2012
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● Also called bulbourethral glands
● Well demarcated lobules of small, compact tubuloalveolar glands resembling minor salivary glands, radiating from a central excretory duct lined by pseudostratified epithelium, and entrapped within fascicles of muscle
● Have a thin connective tissue capsule
● Composed of simple columnar epithelium
● These mucin producing glands are in urogenital diaphragm, resemble mucinous salivary glands in muscle fascicles (Am J Surg Pathol 2001;21:550)
● Seen occasionally in TURP specimens, rarely in needle biopsies
Cowper's gland (CG) in gross anatomy dissection
● Mucin, smooth muscle actin at periphery of acini (Am J Surg Pathol 1997;21:1069)
● PSA (variable), PAP, S100, CEA, CK903 (usually)
● Acini lined by secretory cell layer, with myoepithelial cells at periphery of acini
End of Prostate > Microscopic mimics of prostatic carcinoma > Cowper's glands
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