Prostate - Embryonal rhabdomyosarcoma

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Prostate

Other malignancies

Embryonal rhabdomyosarcoma

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 2 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Most common malignant tumor in children/infants
● Firm, smooth enlargement of prostate
● Nodal metastases less common than in this tumor in head and neck
● Prognosis has improved for children (Int J Cancer 2011;128:1232), but is still poor in adults (Int J Surg Pathol 2011;19:831)
● Usually present with stage 3 disease, sometimes with distant metastases

Prognosis
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● Better if leiomyosarcoma-like appearance

Treatment
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● Multiple agent chemotherapy, surgery and radiation

Micro description
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● Cellular, particularly around blood vessels, alternating with myxoid/edematous areas and necrosis
● Small round / oval / spindly tumor cells
● May have bizarre forms with abundant, eosinophilic cytoplasm, variable cross striations
● Usually extraprostatic extension

Micro images
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Myogenin+

Bladder tumors

Differential diagnosis
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● Bladder rhabdomyosarcoma: may be difficult to distinguish if tumor is large

End of Prostate > Other malignancies > Embryonal rhabdomyosarcoma

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