Table of ContentsDefinition / General | Essential Features | Epidemiology | Clinical Features | Prognostic Factors | Treatment | Micro Description | Micro Images | Differential Diagnosis
Cite this page: Embryonal rhabdomyosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/prostateembryonalrhab.html. Accessed December 7th, 2016.
Definition / General
- Small round cell to spindle cell tumor, variable cellularity
- Occurs in young patients and requires aggressive treatment
- Most common prostatic malignancy in children / infants
- Firm, smooth enlargement of prostate
- Usually presents with stage 3 disease, sometimes with distant metastases
- Multiple agent chemotherapy, surgery and radiation
- Cellularity is greatest around blood vessels, with intervening myxoid and edematous areas and necrosis
- Tumor cells are primitive, round to spindled cells, with purely spindle cell variants being described (Int J Clin Exp Pathol 2014;7:5181)
- May have bizarre forms with abundant eosinophilic cytoplasm, variable cross striations
- Usually extraprostatic extension
- MyoD1 and Myogenin are the most sensitive and specific immunologic markers.
- Bladder rhabdomyosarcoma: may be difficult to distinguish if tumor is large