Prostate gland & seminal vesicles
Other malignancies
Embryonal rhabdomyosarcoma

Topic Completed: 1 November 2016

Minor changes: 8 September 2020

Copyright: 2003-2020,, Inc.

PubMed search: prostatic embryonal rhabdomyosarcoma

Kenneth A. Iczkowski, M.D.
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Cite this page: Iczkowski KA. Embryonal rhabdomyosarcoma. website. Accessed September 20th, 2020.
Definition / general
Essential features
  • Small round cell to spindle cell tumor, variable cellularity
  • Occurs in young patients and requires aggressive treatment
  • Most common prostatic malignancy in children / infants
Clinical features
  • Firm, smooth enlargement of prostate
  • Usually presents with stage 3 disease, sometimes with distant metastases
Prognostic factors
  • Multiple agent chemotherapy, surgery and radiation
Microscopic (histologic) description
  • Cellularity is greatest around blood vessels, with intervening myxoid and edematous areas and necrosis
  • Tumor cells are primitive, round to spindled cells, with purely spindle cell variants being described (Int J Clin Exp Pathol 2014;7:5181)
  • May have bizarre forms with abundant eosinophilic cytoplasm, variable cross striations
  • Usually extraprostatic extension
  • MyoD1 and Myogenin are the most sensitive and specific immunologic markers.
Microscopic (histologic) images

Contributed by Kenneth Iczkowski, M.D.


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Differential diagnosis
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