Prostate
Other malignancies
Embryonal rhabdomyosarcoma

Authors: Kenneth Iczkowski, M.D. (see Authors page)

Revised: 18 November 2016, last major update November 2016

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: prostatic embryonal rhabdomyosarcoma
Cite this page: Embryonal rhabdomyosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/prostateembryonalrhab.html. Accessed December 7th, 2016.
Definition / General
Essential Features
  • Small round cell to spindle cell tumor, variable cellularity
  • Occurs in young patients and requires aggressive treatment
Epidemiology
  • Most common prostatic malignancy in children / infants
Clinical Features
  • Firm, smooth enlargement of prostate
  • Usually presents with stage 3 disease, sometimes with distant metastases
Prognostic Factors
Treatment
  • Multiple agent chemotherapy, surgery and radiation
Micro Description
  • Cellularity is greatest around blood vessels, with intervening myxoid and edematous areas and necrosis
  • Tumor cells are primitive, round to spindled cells, with purely spindle cell variants being described (Int J Clin Exp Pathol 2014;7:5181)
  • May have bizarre forms with abundant eosinophilic cytoplasm, variable cross striations
  • Usually extraprostatic extension
  • MyoD1 and Myogenin are the most sensitive and specific immunologic markers.
Micro Images
Image hosted on PathOut server, contributed by Kenneth Iczkowski, M.D.:

H&E



Images hosted on other servers:

Myogenin+

Bladder tumors

Differential Diagnosis