Embryonal rhabdomyosarcoma

Prostate
Other malignancies
Embryonal rhabdomyosarcoma

Authors: Komal Arora, M.D. (see Authors page)

Revised: 25 August 2016, last major update June 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: prostatic embryonal rhabdomyosarcoma

Table of Contents

Definition / General | Prognosis and Treatment | Micro Description | Micro Images | Differential Diagnosis

Definition / General

Most common malignant tumor in children / infants
Firm, smooth enlargement of prostate
Nodal metastases less common than in this tumor in head and neck
Prognosis has improved for children (Int J Cancer 2011;128:1232), but is still poor in adults (Int J Surg Pathol 2011;19:831)
Usually present with stage 3 disease, sometimes with distant metastases

Prognosis and Treatment

Better if leiomyosarcoma-like appearance
Multiple agent chemotherapy, surgery and radiation

Micro Description

Cellular, particularly around blood vessels, alternating with myxoid / edematous areas and necrosis
Small round / oval / spindly tumor cells
May have bizarre forms with abundant, eosinophilic cytoplasm, variable cross striations
Usually extraprostatic extension

Micro Images

Images hosted on other servers:

Myogenin+

Bladder tumors

Differential Diagnosis

Bladder rhabdomyosarcoma: may be difficult to distinguish if tumor is large