Prostatic carcinoma variants
Foamy gland adenocarcinoma

Authors: Komal Arora, M.D.

Revised: 13 November 2017, last major update March 2012

Copyright: (c) 2003-2017,, Inc.

PubMed search: prostatic foamy gland adenocarcinoma
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Cite this page: Arora, K. Foamy gland adenocarcinoma. website. Accessed January 21st, 2019.
Definition / general
Microscopic (histologic) description
  • Abundant xanthomatous cytoplasm, small hyperchromatic nuclei, minimal / no atypia, pink luminal secretions
  • Hyperchromatic nuclei may make nucleoli difficult to see
  • Cytoplasm differs between malignant and benign glands
  • No obvious basal layer compared to normal glands
  • Foamy morphology comprises most of cancer
  • Usually Gleason score 3+3=6, occasionally Gleason 7 or higher (Am J Surg Pathol 2009;33:583)
  • Needle biopsies may have only a few atypical foamy glands (Ann Diagn Pathol 2008;12:349)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
  • Mucicarmine
  • PAS
  • Lipid
Electron microscopy description
  • Intracytoplasmic vesicles
  • Polyribosomes
Differential diagnosis