Granulomatous lesions
Nonspecific granulomatous prostatitis

Authors: Ali Amin, M.D. (see Authors page)

Revised: 19 July 2016, last major update January 2012

Copyright: (c) 2003-2016,, Inc.

PubMed search: Nonspecific granulomatous prostatitis
Cite this page: Nonspecific granulomatous prostatitis. website. Accessed December 9th, 2016.
Definition / General
  • Rare (< 1%) immune mediated reaction to prostatic secretions released from obstructed ducts
  • Usually associated with nodular hyperplasia in men age 50+

    • Most commonly an incidental finding in Trucut biopsy for rising PSA
    • 20% have triad of high fever, prostatitis symptoms and hard prostate on digital rectal examination
Gross Description
  • Stone hard to firm
  • Obliterated architecture
  • Yellow nodules
Micro Description
  • Granulomas surrounding destroyed prostatic glands or surrounding corpora amylacea
  • Multinucleated giant cells (in 30% of cases)
  • Epithelioid histiocytes
  • Lymphocytes, plasma cells, fibrosis and eosinophils (may be prominent, Arch Pathol Lab Med 1997;121:724)
  • No organisms, no caseation
Micro Images

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Nonspecific granulomatous prostatitis

Negative Stains
Differential Diagnosis
  • Carcinoma: primary, metastatic
  • Infection: acid-fast bacilli, fungi, etc.
  • BCG therapy of bladder carcinoma, post TURP