Prostate - Nonspecific granulomatous prostatitis

Home Chapter Home Jobs Conferences Fellowships Books

Prostate

Granulomatous lesions

Nonspecific granulomatous prostatitis

Reviewers: Ali Amin, M.D., (see Reviewers page)
Revised: 5 January 2012, last major update January 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Rare (< 1%) immune mediated reaction to prostatic secretions released from obstructed ducts
● Usually associated with nodular hyperplasia in men age 50+

Symptoms:
● Most commonly an incidental finding in Trucut biopsy for rising PSA
● 20% have triad of high fever, prostatitis symptoms and hard prostate on digital rectal examination

Gross description
=========================================================================

● Stone hard to firm
● Obliterated architecture
● Yellow nodules

Micro description
=========================================================================

● Granulomas surrounding destroyed prostatic glands or surrounding corpora amylacea
● Multinucleated giant cells (in 30% of cases)
● Epithelioid histiocytes
● Lymphocytes, plasma cells, fibrosis and eosinophils (may be prominent, Arch Pathol Lab Med 1997;121:724)
● No organisms, no caseation

Micro images
=========================================================================

Nonspecific granulomatous prostatitis

Positive stains
=========================================================================

● Histiocytes-lysozyme

Negative stains
=========================================================================

● Histiocytes-PSA/PAP (Am J Clin Pathol 1991;95:330)

Differential Diagnosis
=========================================================================

● Carcinoma: primary, metastatic
● Infection: acid-fast bacilli, fungi, etc.
● BCG therapy of bladder carcinoma, post TURP

End of Prostate > Granulomatous lesions > Nonspecific granulomatous prostatitis

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).