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Benign lesions/conditions

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 16 December 2014, last major update June 2012
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● Rare; glandular hyperplasia with small areas of leiomyomatous growth is more common (Arch Esp Urol 2011;64:631)

Micro description

● Well organized fascicles of spindle cells
● Normocellular; no/rare mitotic activity; no/rare nuclear atypia, but may have atypical bizarre stromal cells (Mod Pathol 2007;20:148, Ann Diagn Pathol 2008;12:328)

Micro images

Degenerative type atypia

Positive stains

● Desmin, actin, androgen receptor

Differential diagnosis

Nodular hyperplasia: no well organized fascicles, no hyalinization, no necrosis, no calcification
Leiomyosarcoma: hypercellular, infiltrative, variable atypia, definite mitotic activity, necrosis

End of Prostate > Benign lesions/conditions > Leiomyoma

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