Prostate gland & seminal vesicles
Other malignancies

Topic Completed: 1 January 2017

Minor changes: 27 February 2019

Copyright: 2003-2019,, Inc.

PubMed search: prostatic leiomyosarcoma

Kenneth A. Iczkowski, M.D.
Page views in 2019: 297
Page views in 2020 to date: 217
Cite this page: Iczkowski KA. Leiomyosarcoma. website. Accessed August 14th, 2020.
Definition / general
  • The most common malignant spindle cell tumor of the prostate
Essential features
  • Rare, but the most common prostatic sarcoma
  • Aggressive
  • Nonsarcomatous spindle cell proliferations must be ruled out
  • Leiomyosarcoma is the most common prostatic sarcoma in adults; it may also occur in children
  • Fewer than 200 cases are reported
Clinical features
  • Tumor causes obstruction, and involves adjacent organs
  • Can initially present with chest metastasis (J Cancer Res Ther 2013;9:743) or in other odd ways
  • Tends to recur
  • Metastases to liver and lung
  • Mean survival 3 - 4 years
Microscopic (histologic) description
  • A spindle cell proliferation with atypia and mitotic activity
  • Focal necrosis may be seen
Microscopic (histologic) images

Contributed by Dr. Athanase Billis, State Univ. of Campinas, Brazil

Images hosted on other servers:

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • Cytogenetics may disclose chromosome 2, 3, 9, 11 and 19 clonal rearrangements
Differential diagnosis
Additional references
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