Other malignancies

Authors: Kenneth Iczkowski, M.D. (see Authors page)

Revised: 24 March 2017, last major update January 2017

Copyright: (c) 2003-2017,, Inc.

PubMed search: prostatic leiomyosarcoma
Cite this page: Leiomyosarcoma. website. Accessed October 17th, 2018.
Definition / general
  • The most common malignant spindle cell tumor of the prostate
Essential features
  • Rare, but the most common prostatic sarcoma
  • Aggressive
  • Nonsarcomatous spindle cell proliferations must be ruled out
  • Leiomyosarcoma is the most common prostatic sarcoma in adults; it may also occur in children
  • Fewer than 200 cases are reported
Clinical features
  • Tumor causes obstruction, and involves adjacent organs
  • Can initially present with chest metastasis (J Cancer Res Ther 2013;9:743) or in other odd ways
  • Tends to recur
  • Metastases to liver and lung
  • Mean survival 3 - 4 years
Microscopic (histologic) description
  • A spindle cell proliferation with atypia and mitotic activity
  • Focal necrosis may be seen
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Athanase Billis, State Univ. of Campinas, Brazil

Images hosted on other servers:

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • Cytogenetics may disclose chromosome 2, 3, 9, 11 and 19 clonal rearrangements
Differential diagnosis
Additional references