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Prostate

Benign lesions/conditions

Melanosis


Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 26 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Melanin within prostatic stromal melanocytes and glandular cells
● Very rare; melanin within glands probably due to stromal cell transfer (Am J Clin Pathol 1988;90:530)
● May be an isolated finding, associated with blue nevus (Eur Urol 1992;22:339), adenocarcinoma (Hum Pathol 2010;18:379, J Urol 1982;128:825), melanoma

Case reports
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● 72 year old man with radical prostatectomy (Case of the Week #137)

Treatment
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● None-no clinical significance by itself

Micro images
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Case of the Week #137: various images

Positive stains
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● S100 (melanocytes)

Electron microscopy
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● Melanosomes

Differential diagnosis
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Lipofuscin: chracteristic of ejaculatory ducts and seminal vesicles but also found in prostatic epithelium, golden yellow-brown to gray-brown granules, positive for Fontana-Masson, PAS with diastase, Congo red, Luxol fast blue, Oil-red-O and Ziehl-Neelsen stains; bleached by permanganate, negative for Prussian blue (Am J Surg Pathol 1994;18:446, Mod Pathol 1996;9:791)
Blue nevus: spindled stromal cells with marked melanin deposition, nevus cells without pigment are usually present

End of Prostate > Benign lesions/conditions > Melanosis


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