Prostate - Mucinous adenocarcinoma from prostatic urethra-urinary bladder type

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Prostate

Other carcinomas

Mucinous adenocarcinoma from prostatic urethra-urinary bladder type

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 23 March 2012, last major update March 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Rare aggressive tumor (Am J Surg Pathol 2007;31:1323) initially described in 1996 in 2 patients with tumors confined to prostate and originating from prostatic urethra (Am J Surg Pathol 1996;20:1346)

Micro description
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● Resemble adenocarcinomas arising within urinary bladder but different from mucinous adenocarcinoma of the prostate (tubules and cribriform glands floating within mucin; mucin+ signet cells are rare)
● Often in situ adenocarcinoma present in overlying prostatic urethra
● Often mucin lakes lined by tall columnar epithelium with variable cytologic atypia
● May resemble intestinal mucinous adenocarcinoma (Int J Urol 2005;12:509)

Micro images
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Various images

Positive stains
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● CEA, CK7, CK20, 34βE12 (Mod Pathol 2005;18:585)

Negative stains
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● PSA, PAP

Differential diagnosis
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● Adenocarcinoma of colonic origin: CK7 variable, CK 20+, 34βE12-
● Classic mucinous prostatic adenocarcinoma: PSA+, PSAP+, CK7-, CK20-,34βE12-

End of Prostate > Other carcinomas > Mucinous adenocarcinoma from prostatic urethra-urinary bladder type

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