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Prostatic carcinoma variants

Mucinous (colloid) adenocarcinoma

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 23 March 2012, last major update March 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Uncommon (< 1%)
● Intra- and extracellular mucin must comprise 25%+ of tumor
● May be more hormone independent, less responsive to radiation therapy
● Aggressive biologic behavior (Am J Surg Pathol 1985;9:299, Am J Surg Pathol 2008;32:468, Mod Pathol 2004;17:316)

Micro description

● Tumor cells float in pools of mucin
● Resembles mucinous (colloid) carcinoma of breast
● Has microglandular, cribriform, comedo, solid and hypernephroid patterns
● Signet ring cells are rare

Micro images

Various images

Positive stains

● PSA, PAP, MUC2 (Mod Pathol 2008;21:789)

Differential diagnosis

● Extension of large bowel carcinoma, Cowpers gland carcinoma
● Mucinous adenocarcinoma of bladder (PSA-,PAP+)
● Post-hormone treatment changes which leave behind acellular pools of mucin (Am J Surg Pathol 1998;22:347)

End of Prostate > Other carcinomas > Mucinous (colloid) adenocarcinoma

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