Prostate
Microscopic mimics of prostatic carcinoma
Mucous gland metaplasia


Topic Completed: 1 August 2016

Revised: 27 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Mucous gland metaplasia

Andres Matoso, M.D.
Page views in 2018: 685
Page views in 2019 to date: 707
Cite this page: Matoso A. Mucous gland metaplasia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/prostatemucousglandhyper.html. Accessed September 22nd, 2019.
Definition / general
  • Mucous gland metaplasia is a form of glandular differentiation
Essential features
  • Acini with tall, mucin filled cells with flat, basal pyknotic nuclei
  • May occur as group of glands or single cells within glands
  • More common in the periurethral area but very infrequent
  • May mimic cancer but not associated with malignancy
  • Resemble Cowper’s glands
Epidemiology
  • Less than 1% of prostates show foci of mucin cell metaplasia
Sites
  • Periurethral area
Pathophysiology
  • Pathophysiology and etiology are unknown
Clinical features
  • The only clinical significance is that it may mimic cancer in a needle biopsy
Diagnosis
  • Morphology
Treatment
  • Not required
  • Mucous gland metaplasia is a morphologica variant of the prostatic acini
Microscopic (histologic) description
  • Acini with tall mucin filled cells with flat, basal pyknotic nuclei
Microscopic (histologic) images

Images hosted on other servers:

Mucinous metaplasia

PSA immunostain

Negative stains
Differential diagnosis
  • The main differential diagnosis is with prostatic ductal adenocarcinoma
  • In contrast to adenocarcinoma, mucous gland metaplasia does not show an infiltrative growth pattern, usually does not display a prominent nucleoli and is positive for basal cell markers p63 and high molecular weight cytokeratin by immunohistochemistry
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