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Prostate

Other carcinomas

Neuroendocrine carcinoma


Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 26 March 2012, last major update March 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Neuroendocrine (NE) cells found in 80% of normal prostates, 10-33% of adenocarcinomas
● Prostatic NE cells most likely derive from local stem cells and represent terminally differentiated and androgen-insensitive cell populations in benign prostate tissue (Ann Oncol 2001;12:S141)
● Extent of neuroendocrine differentiation may provide prognostic information in tumors with Gleason score 2-6 treated by radical prostatectomy (Hum Pathol 1996;27:683, Urologe A 2004;43:836, Indian J Urol 2010;26:41)
● Pure neuroendocrine carcinomas not associated with elevated PSA
● NE differentiation arises in three different forms: carcinoid, oat cell carcinoma, focally NE-differentiated conventional tumor
● Selective expression of stem cell-associated markers, such as CD44/Oct4A gene, in NE cancerous cells explain their therapy escape together with tumor recurrence and metastasis (G Chir 2010;31:586)

Case reports
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● 55 year old man (Pol J Pathol 2011;62:60)
● 73 year old man (Arch Pathol Lab Med 2000;124:1074)

Micro description
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● May resemble Paneth cells with large, basal, eosinophilic granules
● Also resemble typical or atypical carcinoid

Micro images
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Various images

Recurrent neuroendocrine carcinoma


PSA/chromogranin

Positive stains
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● Chromogranin, PSA, PAP
● Bcl2, ACTH, β-endorphin, calcitonin

End of Prostate > Other carcinomas > Neuroendocrine carcinoma


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