Prostate
Other carcinomas
Neuroendocrine overview

Author: Debra L. Zynger, M.D. (see Authors page)

Revised: 20 June 2016, last major update June 2016

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: Prostatic neuroendocrine carcinoma
Cite this page: Neuroendocrine overview. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/prostateneuroendo.html. Accessed December 2nd, 2016.
Definition / General
  • Neuroendocrine cells are found in normal prostate glands between basal cells and secretory cells
  • Neuroendocrine differentiation can be seen in prostate cancer and is categorized based on the extent as:
    • Neuroendocrine cells in usual prostate adenocarcinoma
    • Adenocarcinoma with Paneth cell-like neuroendocrine differentiation
    • Well differentiated neuroendocrine tumor (formerly termed carcinoid)
    • Small cell neuroendocrine carcinoma
    • Large cell neuroendocrine carcinoma
  • Reported frequency of neuroendocrine cells in usual prostate adenocarcinoma is variable (10 - 100%) and the presence does not change clinical management (Hum Pathol 2000;31:406, Am J Surg Pathol 2014;38:756)
  • Paneth cell-like neuroendocrine differentiation in prostatic adenocarcinoma has no established prognostic significance (Am J Surg Pathol 2006;30:980)
  • Well differentiated neuroendocrine tumor (formerly termed carcinoid) is extremely rare, should only be diagnosed if conventional prostate cancer is not present, and has a good prognosis despite presenting with disease that is locally advanced or within regional lymph nodes
  • Small cell neuroendocrine carcinoma of the prostate has a prior history of conventional prostate cancer in half of cases, and is important to recognize because platinum based chemotherapy is utilized for treatment
  • Most cases of large cell neuroendocrine carcinoma occur after long term androgen ablation (Am J Surg Pathol 2006;30:684)
Case Reports
Micro Description
  • Neuroendocrine cells in normal prostate ducts and acini are not identifiable on routine H&E
  • Paneth cell-like neuroendocrine differentiation in prostatic adenocarcinoma is characterized by cells with bright, eosinophilic granules
  • Small cell neuroendocrine carcinoma of the prostate has similar morphology to other organs (sheets of small cells with minimal cytoplasm, indistinct cell borders, nuclear molding, crush, necrosis, apoptotic bodies, high mitotic rate, uniform chromatin, lack of nucleoli) although intermediate cell size and pinpoint nucleoli are acceptable for this diagnosis
Micro Images

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Images hosted on PathOut server:

Prostatic adenocarcinoma with 100% NE differentiation
status - post-brachytherapy & androgen deprivation therapy


Prostatic small cell neuroendocrine carcinoma


Metastatic prostatic small cell neuroendocrine carcinoma



Images hosted on other servers:

Recurrent neuroendocrine carcinoma

PSA / chromogranin

Positive Stains
Negative Stains