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Benign lesions/conditions

Paneth cell-like change

Reviewers: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 3 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Associated with both benign and malignant lesions (Arch Pathol Lab Med 1992;116:274)
● Collections of prostatic cells with eosinophilic granules resembling intestinal Paneth cells (Am J Surg Pathol 1992;16:1013)
● Represents either (a) PAS-positive and diastase-resistant eosinophilic cytoplasmic granular change in benign prostatic epithelium, or (b) endocrine differentiation with neuroendocrine granules in dysplastic and malignant prostatic epithelia (Am J Surg Pathol 1992;16:62, Hum Pathol 1994;25:135, Am J Surg Pathol 2006;30:980)

Positive stains

● PAS+ diastase resistant (benign epithelium), neuroendocrine markers (dysplastic/malignant epithelium), PSA

Negative stains

● Lysozyme

Electron microscopy

● Exocrine-like or lysosomal-like vesicles in benign epithelium, neuroendocrine granules in dysplastic / malignant epithelium

Virtual slides

Adenocarcinoma of the Prostate with Paneth cell-like Neuroendocrine Differentiation

End of Prostate > Benign lesions/conditions > Paneth cell-like change

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