Microscopic mimics of prostatic carcinoma
Paraganglion tissue

Author: Andres Matoso, M.D. (see Authors page)

Revised: 22 August 2016, last major update August 2015

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Paraganglion [title] tissue
Cite this page: Paraganglion tissue. website. Accessed October 17th, 2018.
Definition / general
  • Group of neuroendocrine cells derived from neural crest
  • Usually located in posterolateral soft tissue outside of prostate
  • Seen in radical prostatectomy specimens and rarely in prostate needle biopsies, or in smooth muscle of bladder neck in transurethral resections of prostate or bladder
Microscopic (histologic) description
  • Group of cells with clear, vacuolated or amphophilic cytoplasm with a delicate blood vessel meshwork
  • Nuclei may show prominent nucleoli or degenerative endocrine type atypia
Microscopic (histologic) images

Images hosted on other servers:

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Compact cluster of polygonal cells

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Granular amphophilic cytoplasm

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Associated with a nerve

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Cells with clear/amphophilic cytoplasm

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Images courtesy of Andres Matoso, M.D.:

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Chromogranin A+

Differential diagnosis
  • The main differential diagnosis is with Gleason pattern 5 prostate cancer
    • The degenerative type atypia in paraganglions is helpful when present; also absence of surrounding prostate glands
    • Immunohistochemistry for prostate markers and cytokeratin is helpful