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Microscopic mimics of prostatic carcinoma

Paraganglion tissue

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 22 May 2014, last major update June 2012
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.


● Present in periprostatic soft tissue, in or adjacent to lateral neurovascular bundles
● Rarely in lateral prostatic stroma
● Size 0.1 to 1.7 mm

Micro description

● Clusters or nests of epithelioid cells, lateral to diffuse, usually with prominent stromal vascular component
● Bland round to oval nuclei, basophilic granular or vacuolated cytoplasm
● In needle biopsies, may be mistaken for high-grade prostate cancer due to cells with vacuolated cytoplasm (mimicking ‘hypernephroid’ prostate cancer), often in periprostatic tissue, and lack of discrete glands

Micro images

Various images

Positive stains

● Chromogranin A, neuron-specific enolase, synaptophysin

Negative stains

● PAP, PSA, low molecular weight cytokeratin

Additional references

Arch Pathol Lab Med 1997;121:515, Am J Surg Pathol 1994;18:412, Histopathology 2005;47:114

End of Prostate > Microscopic mimics of prostatic carcinoma > Paraganglion tissue

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