Primitive peripheral neuroectodermal tumor / PNET
Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 26 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
See also Kidney tumor topic
● 31 year old man (Arch Pathol Lab Med 2003;127:e190)
● Solid nests and sheets of small round cells
Various images (from GU, not necessarily prostate)
● CD99/MIC2, vimentin, neuron-specific enolase, synaptophysin
● EWS/FLI1 type 2 chimeric transcript
● Desmoplastic small round cell tumor: keratin+, desmin+, WT1+ (Int J Urol 2009;16:769)
● Lymphoma: 90% of lymphoblastic lymphoma are CD99+ but also TdT+ and EWS/FLI1 negative
● Rhabdomyosarcoma: muscle markers+, 20% are CD99+
● Small cell carcinoma: solid growth, variable rosettes, CD99-
End of Prostate > Other malignancies > Primitive peripheral neuroectodermal tumor / PNET
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