Prostate - Primitive peripheral neuroectodermal tumor / PNET

Home Chapter Home Jobs Conferences Fellowships Books

Prostate

Other malignancies

Primitive peripheral neuroectodermal tumor / PNET

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 26 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

See also Kidney tumor topic

General
=========================================================================

● 31 year old man (Arch Pathol Lab Med 2003;127:e190)

Micro description
=========================================================================

● Solid nests and sheets of small round cells

Micro images
=========================================================================

Various images

Various images (from GU, not necessarily prostate)

Positive stains
=========================================================================

● CD99/MIC2, vimentin, neuron-specific enolase, synaptophysin

Molecular description
=========================================================================

● EWS/FLI1 type 2 chimeric transcript

Differential diagnosis
=========================================================================

● Desmoplastic small round cell tumor: keratin+, desmin+, WT1+ (Int J Urol 2009;16:769)
● Lymphoma: 90% of lymphoblastic lymphoma are CD99+ but also TdT+ and EWS/FLI1 negative
● Rhabdomyosarcoma: muscle markers+, 20% are CD99+
● Small cell carcinoma: solid growth, variable rosettes, CD99-

End of Prostate > Other malignancies > Primitive peripheral neuroectodermal tumor / PNET

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).