Prostate - Postoperative spindle cell nodules

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Prostate

Benign lesions/conditions

Postoperative spindle cell nodules

Reviewers: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 20 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

Primary carcinoma

General
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● Exuberant stromal reaction occurring weeks to months after TURP that resembles a sarcoma and may cause postoperative bleeding (J Urol 1990;143:824, Virchows Arch 2002;441:231)

Gross description
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● Friable red nodules, resembling granulation tissue or sarcoma

Micro description
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● Cellular with high mitotic activity
● Intersecting fascicles of spindle cells with extravasated red blood cells resembling Kaposi’s sarcoma
● Minimal nuclear pleomorphism, no atypical mitoses
● Relatively small size

Micro images
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Bladder tumors (similar histology)

Positive stains
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● Keratin (strong), actin (variable)

Negative stains
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● EMA

End of Prostate > Benign lesions/conditions > Postoperative spindle cell nodules

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