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Prostate

Miscellaneous

Features to report


Reviewer: Komal Arora, M.D., (see Reviewers page)
Revised: 26 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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Prostatectomies:
● Structures included in specimen (prostate [complete or not], seminal vesicles, vas deferens, bladder neck)
● Weight, size in 3 dimensions
● Histologic type and location of tumor (if any)
● Gleason pattern/grade and score
● % of prostate involved by tumor (need not give volume but an indication of minute vs. voluminous)
● Presence of perineural invasion (diameter may be prognostic factor (Hum Pathol 2001;32:828)
● Presence of angiolymphatic invasion (Am J Surg Pathol 1996;20:1351, J Urol 2005;174:2181)
● Presence of extraprostatic tissue invasion
● Presence of high grade PIN
● Margins
● Lymph nodes (# involved, # sampled) and diameter of largest metastasis (Am J Surg Pathol 1998;22:1491)
● Acute or chronic inflammation (often doesn’t correlate with clinical prostatitis)
● Granulomatous prostatitis (may elevate PSA, produce suspicious feeling gland)
Note: extranodal tumor extension not related to survival (Mod Pathol 2000;13:113)

Biopsies (core or transurethral prostate resection:
● Histologic type
● Gleason primary and secondary grades and total score
● # cores involved, # cores total
● % of prostatic tissue involved by tumor or total linear mm of carcinoma / total linear mm of tissue
● Presence of perineural, angiolymphatic, periprostatic fat invasion, seminal vesicle invasion, extraprostatic tissue invasion
● Presence of high grade PIN (if no carcinoma, report # of cores involved and pattern of high grade PIN)
● Therapy related changes

Additional references
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Arch Pathol Lab Med 2009;133:1568, Hum Pathol 2007;38:1305

End of Prostate > Miscellaneous > Features to report


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