Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 21 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● Occurs in 2-10% of radical prostatectomies (Turk Patoloji Derg 2012;28:44)
● Incidence increases with age, reaching 21% in men age 75 years and older (Histopathology 1993;22:173, Am J Pathol 1983;110:64)
● Usually a localized finding
● Vessels or prostatic stroma are not part of this process
● Amyloidosis develops subepithelially spreading to include the wall of seminal vesicles and ejaculatory ducts; appears to be related to advanced age (Ann Diagn Pathol 2008;12:235)
● Although immunohistochemistry often detects lactoferrin (Ann Pathol 2004;24:236), amyloid apparently derives from semenogelin I, the major secretory product of the seminal vesicles (J Lab Clin Med 2005;145:187)
● Semenogelin I and II are mainly responsible for immediate gel formation of freshly ejaculated semen, and are degraded by the proteolytic action of prostate specific antigen/PSA (J Androl 1996;17:17)
● 66 year old man with prostatectomy for adenocarcinoma (Case of Week #85)
66 year old man with radical prostatectomy for adenocarcinoma
● Trichrome (stains amyloid dusky gray), Congo Red
● Nonbranching fibrils (Mod Pathol 1989;2:671)
End of Prostate > Seminal vesicles > Amyloidosis
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