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Prostate

Seminal vesicles

Carcinoma


Reviewer: Komal Arora, M.D. (see Reviewers page)
Revised: 29 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

Primary carcinoma

General
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● Very rare, must confirm microscopically
● Primary tumors should be localized primarily to seminal vesicle; must rule out invasion from prostate (do PSA/PAP), rectum or other sites
● Usually a papillary adenocarcinoma resembling architecture of normal seminal vesicle
● Resembles prostatic duct adenocarcinoma Gleason patterns 3 or 4 or mucinous (colloid) carcinoma
● Usually unresectable and patients die within 2 years
● Adenocarcinoma: very rare, must rule out prostate primary; often mucin producing, ulcerates through skin of scrotum

Case reports
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● 67 year old man with neuroendocrine carcinoma (Int J Urol 2012;19:370)
● 87 year old man (Hum Pathol 1987;18:200)
● Disseminated disease with occult primary discovered at autopsy (Int J Surg Pathol 2011;19:401)

Gross images
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Low grade epithelial stromal tumor

Micro images
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Primary seminal vesicle adenocarcinoma

   
Primary seminal vesicle adenocarcinoma: CK7 (left) and CA125 (right)

       
Metastatic hepatocellular carcinoma

       
Low grade epithelial stromal tumor

Positive stains
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● CK7, CA125 (Mod Pathol 2000;13:46)

Negative stains
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● PSA, PAP, CK20

Differential diagnosis
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Table of immunostains

Bladder adenocarcinoma: CA125-
Bladder urothelial carcinoma: CK20+, CA125-
Prostatic adenocarcinoma: PSA+, PAP+, CA125-
Rectal adenocarcinoma: CA125-, CK7 neg, CK20+

End of Prostate > Seminal vesicles > Carcinoma


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