Prostate gland & seminal vesicles
Seminal vesicles
Adenocarcinoma
Author: Komal Arora, M.D.
Last author update: 1 July 2012
Last staff update: 14 October 2022
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed search: prostatic seminal vesicle carcinoma
Table of Contents
Definition / general | Case reports | Gross images | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Arora K. Adenocarcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/prostatesemca.html. Accessed April 25th, 2024.
Definition / general
- Very rare, must confirm microscopically
- Primary tumors should be localized primarily to seminal vesicle; must rule out invasion from prostate (do PSA / PAP), rectum or other sites
- Usually a papillary adenocarcinoma resembling architecture of normal seminal vesicle
- Resembles prostatic duct adenocarcinoma Gleason patterns 3 or 4 or mucinous (colloid) carcinoma
- Usually unresectable and patients die within 2 years
- Adenocarcinoma: very rare, must rule out prostate primary; often mucin producing, ulcerates through skin of scrotum
Case reports
- 67 year old man with neuroendocrine carcinoma (Int J Urol 2012;19:370)
- 87 year old man (Hum Pathol 1987;18:200)
- Disseminated disease with occult primary discovered at autopsy (Int J Surg Pathol 2011;19:401)
Gross images
Images hosted on other servers:
Low grade epithelial stromal tumor
Microscopic (histologic) images
Images hosted on other servers:
Metastatic hepatocellular carcinoma
Low grade epithelial stromal tumor
Positive stains
Differential diagnosis
- Bladder adenocarcinoma: CA125-
- Bladder urothelial carcinoma: CK20+, CA125-
- Prostatic adenocarcinoma: PSA+, PAP+, CA125-
- Rectal adenocarcinoma: CA125-, CK7 neg, CK20+
