Prostate - Seminal vesicles

Home Chapter Home Jobs Conferences Fellowships Books

Prostate

Seminal vesicles

Carcinoma

Reviewer: Komal Arora, M.D. (see Reviewers page)
Revised: 29 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

Primary carcinoma

General
=========================================================================

● Very rare, must confirm microscopically
● Primary tumors should be localized primarily to seminal vesicle; must rule out invasion from prostate (do PSA/PAP), rectum or other sites
● Usually a papillary adenocarcinoma resembling architecture of normal seminal vesicle
● Resembles prostatic duct adenocarcinoma Gleason patterns 3 or 4 or mucinous (colloid) carcinoma
● Usually unresectable and patients die within 2 years
● Adenocarcinoma: very rare, must rule out prostate primary; often mucin producing, ulcerates through skin of scrotum

Case reports
=========================================================================

● 67 year old man with neuroendocrine carcinoma (Int J Urol 2012;19:370)
● 87 year old man (Hum Pathol 1987;18:200)
● Disseminated disease with occult primary discovered at autopsy (Int J Surg Pathol 2011;19:401)

Gross images
=========================================================================

Low grade epithelial stromal tumor

Micro images
=========================================================================

Primary seminal vesicle adenocarcinoma


Primary seminal vesicle adenocarcinoma: CK7 (left) and CA125 (right)


Metastatic hepatocellular carcinoma


Low grade epithelial stromal tumor

Positive stains
=========================================================================

● CK7, CA125 (Mod Pathol 2000;13:46)

Negative stains
=========================================================================

● PSA, PAP, CK20

Differential diagnosis
=========================================================================

Table of immunostains

● Bladder adenocarcinoma: CA125-
● Bladder urothelial carcinoma: CK20+, CA125-
● Prostatic adenocarcinoma: PSA+, PAP+, CA125-
● Rectal adenocarcinoma: CA125-, CK7 neg, CK20+

End of Prostate > Seminal vesicles > Carcinoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).