Prostate - Signet ring nodule

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Prostate

Benign lesions/conditions

Signet ring nodule

Reviewers: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 21 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

Case reports
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● 66 year old man with benign prostatic hyperplasia (WebMed Central 22 Sep 2010)

Micro description
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● Stromal nodule with short spindly cells with bland nuclear features, but also large, clear cytoplasmic vacuoles in many cells resembling signet-ring carcinoma cells but non-infiltrative (Am J Surg Pathol 2002;26:1066)
● Associated with degenerated lymphocytes (Am J Surg Pathol 1986;10:795)

Micro images
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Signet ring cell change in benign prostatic hyperplasia

Positive stains
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● Vimentin, desmin (weak)

Negative stains
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● Mucin

Differential diagnosis
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● Signet ring carcinoma: infiltrative tumor cells with signet ring pattern (at least 25%) due to intracellular accumulation of mucin compressing the nucleus into a crescent shape; mucin+

End of Prostate > Benign lesions/conditions > Signet ring nodule

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