Benign lesions / conditions
Signet ring cell nodule

Author: Monika Roychowdhury, M.D.

Revised: 3 August 2018, last major update July 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: prostatic signet ring cell nodule
Page views in 2018: 169
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Cite this page: Roychowdhury, M. Signet ring cell nodule. website. Accessed February 19th, 2019.
Case reports
Microscopic (histologic) description
  • Stromal nodule with short spindly cells with bland nuclear features but also large, clear cytoplasmic vacuoles in many cells resembling signet ring cell carcinoma cells but noninfiltrative (Am J Surg Pathol 2002;26:1066)
  • Associated with degenerated lymphocytes (Am J Surg Pathol 1986;10:795)
Microscopic (histologic) images

Images hosted on other servers:

Signet ring cell
change in benign
prostatic hyperplasia

Positive stains
  • Vimentin, desmin (weak)
Negative stains
  • Mucin
Differential diagnosis
  • Signet ring cell carcinoma: infiltrative tumor cells with signet ring cell pattern (at least 25%) due to intracellular accumulation of mucin compressing the nucleus into a crescent shape; mucin+