Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Prostate

Benign lesions/conditions

Signet ring nodule


Reviewers: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 21 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

Case reports
=========================================================================

● 66 year old man with benign prostatic hyperplasia (WebMed Central 22 Sep 2010)

Micro description
=========================================================================

● Stromal nodule with short spindly cells with bland nuclear features, but also large, clear cytoplasmic vacuoles in many cells resembling signet-ring carcinoma cells but non-infiltrative (Am J Surg Pathol 2002;26:1066)
● Associated with degenerated lymphocytes (Am J Surg Pathol 1986;10:795)

Micro images
=========================================================================



Signet ring cell change in benign prostatic hyperplasia

Positive stains
=========================================================================

● Vimentin, desmin (weak)

Negative stains
=========================================================================

● Mucin

Differential diagnosis
=========================================================================

Signet ring carcinoma: infiltrative tumor cells with signet ring pattern (at least 25%) due to intracellular accumulation of mucin compressing the nucleus into a crescent shape; mucin+


End of Prostate > Benign lesions/conditions > Signet ring nodule


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).