Benign lesions / conditions
Signet ring nodule

Authors: Monika Roychowdhury, M.D. (see Authors page)

Revised: 29 July 2016, last major update July 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: prostatic signet ring nodule
Cite this page: Signet ring nodule. website. Accessed May 24th, 2018.
Case reports
Microscopic (histologic) description
  • Stromal nodule with short spindly cells with bland nuclear features, but also large, clear cytoplasmic vacuoles in many cells resembling signet-ring carcinoma cells but non-infiltrative (Am J Surg Pathol 2002;26:1066)
  • Associated with degenerated lymphocytes (Am J Surg Pathol 1986;10:795)
Microscopic (histologic) images

Images hosted on other servers:

Signet ring cell change in benign prostatic hyperplasia

Positive stains
  • Vimentin, desmin (weak)
Negative stains
  • Mucin
Differential diagnosis
  • Signet ring carcinoma: infiltrative tumor cells with signet ring pattern (at least 25%) due to intracellular accumulation of mucin compressing the nucleus into a crescent shape; mucin+