Prostate gland & seminal vesicles
Benign lesions/conditions
Signet ring cell nodule
Author: Monika Roychowdhury, M.D.
Topic Completed: 1 July 2012
Minor changes: 26 February 2019
Copyright: 2003-2019, PathologyOutlines.com, Inc.
PubMed Search: prostatic signet ring cell nodule
Table of Contents
Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Roychowdhury M. Signet ring cell nodule. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/prostatesignetringnodule.html. Accessed August 14th, 2020.
Case reports
- 66 year old man with benign prostatic hyperplasia (WebMed Central 22 Sep 2010)
Microscopic (histologic) description
- Stromal nodule with short spindly cells with bland nuclear features but also large, clear cytoplasmic vacuoles in many cells resembling signet ring cell carcinoma cells but noninfiltrative (Am J Surg Pathol 2002;26:1066)
- Associated with degenerated lymphocytes (Am J Surg Pathol 1986;10:795)
Microscopic (histologic) images
Images hosted on other servers:
Signet ring cell
change in benign
prostatic hyperplasia
Positive stains
- Vimentin, desmin (weak)
Negative stains
- Mucin
Differential diagnosis
- Signet ring cell carcinoma: infiltrative tumor cells with signet ring cell pattern (at least 25%) due to intracellular accumulation of mucin compressing the nucleus into a crescent shape; mucin+
