Signet ring cell nodule

Prostate
Benign lesions / conditions
Signet ring cell nodule

Author: Monika Roychowdhury, M.D.

Revised: 3 August 2018, last major update July 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: prostatic signet ring cell nodule

Table of Contents

Cite this page: Roychowdhury, M. Signet ring cell nodule. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/prostatesignetringnodule.html. Accessed November 21st, 2018.

Case reports

66 year old man with benign prostatic hyperplasia (WebMed Central 22 Sep 2010)

Microscopic (histologic) description

Stromal nodule with short spindly cells with bland nuclear features but also large, clear cytoplasmic vacuoles in many cells resembling signet ring cell carcinoma cells but noninfiltrative (Am J Surg Pathol 2002;26:1066)
Associated with degenerated lymphocytes (Am J Surg Pathol 1986;10:795)

Microscopic (histologic) images

Images hosted on other servers:

Signet ring cell
change in benign
prostatic hyperplasia

Positive stains

Vimentin, desmin (weak)

Negative stains

Mucin

Differential diagnosis

Signet ring cell carcinoma: infiltrative tumor cells with signet ring cell pattern (at least 25%) due to intracellular accumulation of mucin compressing the nucleus into a crescent shape; mucin+