Signet ring nodule
Reviewers: Monika Roychowdhury, M.D., (see Reviewers page)
Revised: 21 July 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.
● 66 year old man with benign prostatic hyperplasia (WebMed Central 22 Sep 2010)
● Stromal nodule with short spindly cells with bland nuclear features, but also large, clear cytoplasmic vacuoles in many cells resembling signet-ring carcinoma cells but non-infiltrative (Am J Surg Pathol 2002;26:1066)
● Associated with degenerated lymphocytes (Am J Surg Pathol 1986;10:795)
Signet ring cell change in benign prostatic hyperplasia
● Vimentin, desmin (weak)
● Signet ring carcinoma: infiltrative tumor cells with signet ring pattern (at least 25%) due to intracellular accumulation of mucin compressing the nucleus into a crescent shape; mucin+
End of Prostate > Benign lesions/conditions > Signet ring nodule
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