Signet ring nodule

Prostate
Benign lesions / conditions
Signet ring nodule

Authors: Monika Roychowdhury, M.D. (see Authors page)

Revised: 29 July 2016, last major update July 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: prostatic signet ring nodule

Table of Contents

Case Reports

66 year old man with benign prostatic hyperplasia (WebMed Central 22 Sep 2010)

Micro Description

Stromal nodule with short spindly cells with bland nuclear features, but also large, clear cytoplasmic vacuoles in many cells resembling signet-ring carcinoma cells but non-infiltrative (Am J Surg Pathol 2002;26:1066)
Associated with degenerated lymphocytes (Am J Surg Pathol 1986;10:795)

Micro Images

Images hosted on other servers:

Signet ring cell change in benign prostatic hyperplasia

Positive Stains

Vimentin, desmin (weak)

Negative Stains

Mucin

Differential Diagnosis

Signet ring carcinoma: infiltrative tumor cells with signet ring pattern (at least 25%) due to intracellular accumulation of mucin compressing the nucleus into a crescent shape; mucin+