Table of Contents
Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Roychowdhury, M. Signet ring cell nodule. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/prostatesignetringnodule.html. Accessed February 19th, 2019.
Case reports
- 66 year old man with benign prostatic hyperplasia (WebMed Central 22 Sep 2010)
Microscopic (histologic) description
- Stromal nodule with short spindly cells with bland nuclear features but also large, clear cytoplasmic vacuoles in many cells resembling signet ring cell carcinoma cells but noninfiltrative (Am J Surg Pathol 2002;26:1066)
- Associated with degenerated lymphocytes (Am J Surg Pathol 1986;10:795)
Microscopic (histologic) images
Positive stains
- Vimentin, desmin (weak)
Negative stains
- Mucin
Differential diagnosis
- Signet ring cell carcinoma: infiltrative tumor cells with signet ring cell pattern (at least 25%) due to intracellular accumulation of mucin compressing the nucleus into a crescent shape; mucin+