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Prostate

Other carcinomas

Small cell carcinoma


Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 26 March 2012, last major update March 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Pure or combined with ordinary ductal adenocarcinoma
● Diagnosis restricted to cases having either pure or mixed with an adenocarcinoma component, where the cells resemble small-cell carcinoma of the lung (and elsewhere) histologically
● Serum PSA levels are often not elevated
● May cause Cushing’s syndrome, syndrome of inappropriate antidiuretic hormone secretion
● Some have endocrine features
● Very aggressive, cannot monitor with PSA (unreliable)
● Survival usually less than 1 year (Arch Pathol Lab Med 1986;110:1041)
● Rarely associated with limbic encephalitis (Mod Pathol 1999;12:814)

Micro description
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● Usually large number of apoptotic cells; otherwise resembles lung small cell carcinoma
● Typical features of small cell carcinoma, including high mitotic rate, frequent apoptotic bodies, crush artifact and DNA encrustation of blood vessel walls (Azzopardi phenomenon) are present

Micro images
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Various images

   
Immunostains

Positive stains
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● Chromogranin, NSE, TTF1 (Mod Pathol 2000;13:238), CD56 (Am J Surg Pathol 2008;32:65)

Negative stains
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● PSA, PAP (Am J Surg Pathol 2008;32:65)

Differential diagnosis
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● Large cell neuroendocrine carcinoma: extremely rare, described in case reports and in one small study; large and polygonal tumor cells with moderate to abundant cytoplasm, coarsely granular nuclear chromatin and prominent nucleoli (Mod Pathol 2006;19:1358)

End of Prostate > Other carcinomas > Small cell carcinoma


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