Other malignancies
Stromal sarcomas

Authors: Kenneth A. Iczkowski, M.D. (see Authors page)

Revised: 21 June 2017, last major update June 2017

Copyright: (c) 2003-2017,, Inc.

PubMed search: Prostatic stromal sarcoma

Related topics: Stromal proliferation of uncertain malignant potential
Cite this page: Stromal sarcomas. website. Accessed July 26th, 2017.
Definition / general
  • A rare entity (Pathology 2013 Feb;45:104)
  • Usually presents with urinary retention; also abnormal digital rectal examination, hematuria or hematospermia, palpable rectal mass
  • Includes phyllodes tumors (like those of the breast)
Essential features
  • Cellular pleomorphism exceeding that of stromal proliferation of undetermined malignant potential
  • Necrosis
  • Mitotic activity
  • Extension outside the prostate
ICD-10 coding
  • C61 Malignant neoplasm of prostate
Case reports
Microscopic (histologic) description
  • Greater cellularity, mitotic activity, necrosis, and stromal overgrowth than “stromal tumor of uncertain malignant potential”
  • There may be either pure stromal elements or stromal elements with benign glands resembling malignant breast phyllodes tumor
Microscopic (histologic) images
Images hosted on other servers:

Various images

Positive stains
Negative stains
Differential diagnosis
Board review question #1
Two of the most consistently positive and useful markers for prostatic stromal sarcoma are:

A. Estrogen receptor and CD34
B. S100 protein and HHF35 muscle marker
C. CD34 and progesterone receptor
D. Desmin and S100 protein
E. Smooth muscle actin and estrogen receptor
Board review answer #1
C. CD34 and progesterone receptor