Prostate - Stromal sarcomas

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Prostate

Other malignancies

Stromal sarcomas

Reviewers: Komal Arora, M.D., (see Reviewers page)
Revised: 22 June 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

See also Stromal proliferation of uncertain malignant potential, Stromal sarcomas

General
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● Mean age 54, peak incidence in 50’s and 60’s (Am J Surg Pathol 1998;22:148)
● Usually presents with urinary retention
● Also abnormal digital rectal examination, hematuria or hematospermia, palpable rectal mass
● Includes phyllodes tumors

Case reports
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● 31 year old with stromal sarcoma with rhabdoid features (Ann Diagn Pathol 2010;14:453)
● 52 year old with recurrent tumor (J Clin Pathol 2007;60:330)
● 71 year old with urinary obstruction (Case Reports in Pathology 2011;2011 (Article ID 252805))

Micro description
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● Greater cellularity, mitoses, necrosis, and stromal overgrowth than tumors of “uncertain malignant potential”
● Either pure stromal elements or stromal elements with benign glands resembling malignant breast phyllodes tumors

Micro images
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Various images

Positive stains
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● Vimentin (100%), CD34 (100%), progesterone receptor (85%), desmin (50%), smooth muscle actin (33%), HHF-35 (25%)

Negative stains
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● S100 (100%), ER (usually)

Differential diagnosis
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● Stromal proliferation of uncertain malignant potential

End of Prostate > Other malignancies > Stromal sarcomas

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