Synovial sarcoma

Prostate
Other malignancies
Synovial sarcoma

Authors: Komal Arora, M.D. (see Authors page)

Revised: 1 September 2016, last major update June 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: prostatic synovial sarcoma

Related topics: Soft tissue tumor chapter

Table of Contents

Definition / General

37 year old man with monophasic tumor (Am J Surg Pathol 1999;23:220)

Micro Description

Uniform spindle and oval cells forming interlacing fascicles resembling fibrosarcoma
Focally the compact fascicles of tumor cells alternate with hypocellular myxoid tissue resembling peripheral nerve sheath tumors, focal pericytomatous pattern of polygonal cells arranged around dilated, thin walled blood vessels

Micro Images

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Positive Stains

Vimentin (most cells), EMA (focal)

Negative Stains

S100, keratin, neuron-specific enolase, CD34, desmin, muscle specific actin, alpha smooth muscle actin

Molecular / Cytogenetics Description

t(X;18)(p11.2;q11.2) (Int J Surg Pathol 2008;16:329)