Prostate - Infectious (Tuberculosis and BCG-therapy related) granulomatous prostatitis

Home Chapter Home Jobs Conferences Fellowships Books

Prostate

Granulomatous lesions

Infectious (Tuberculosis and BCG-therapy related) granulomatous prostatitis

Reviewers: Ali Amin, M.D., (see Reviewers page)
Revised: 7 January 2012, last major update January 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Prostate is the most common site for tuberculosis in male GU tract (involved in >90% of cases with GU tuberculosis), due to hematogenous spread from lungs or direct incasion from urethra

Clinical features
=========================================================================

● Tuberculosis may perforate into urethra and extend into bladder or rectum
● Tuberculosis symptoms: fluctuant tender zones, usually bilateral, on digital rectal examination
● May cause a self limited rise in PSA in acute phase that can remain high for months
● Similar histologic findings due to intravesical treatment with bacillus Calmette-Guerin (bCG) for bladder carcinoma

Treatment
=========================================================================

● None required for bCG therapy, although rarely disseminates as tuberculosis

Micro description
=========================================================================

Tuberculosis:
● Granulomas with/without caseating necrosis next to benign glands
● May calcify or become small and fibrotic, resembling carcinoma

BCG-therapy:
● Causes caseating or non-caseating granulomas located next to benign prostatic glands (not engulfing them)
● Usually AFB negative
● Located along periurethral or transition zone or diffuse

Micro images
=========================================================================

Various images

End of Prostate > Granulomatous lesions > Infectious (Tuberculosis and BCG-therapy related) granulomatous prostatitis

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).