Microscopic mimics of prostatic carcinoma
Verumontanum mucosal hyperplasia

Author: Andres Matoso, M.D. (see Authors page)

Revised: 24 September 2015, last major update September 2015

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Verumontanum mucosal hyperplasia
Definition / General
  • Well circumscribed small acinar proliferation in or adjacent to verumontanum and posterior prostatic urethra
  • Sites
  • The verumontanum is located in the posterior aspect of the prostatic urethra
  • It is the area where the utricle and the ejaculatory ducts merge with the urethra
  • Clinical Features
  • The presence of verumontanum mucosa gland hyperplasia is an asymptomatic morphologic variant of the glands underlying the posterior wall of the prostatic urethra
  • Diagnosis
  • Can be identified in TURP specimens or in needle biopsies of the prostate
  • Case Reports
  • 5 cases of verumontanum mucosal gland hyperplasia in prostatic needle biopsy specimens (Am J Clin Pathol 1995;104:620)
  • Treatment
  • Not required
  • Micro Description
  • Crowded small acinar proliferation, usually arranged in a well circumscribed nodule
  • The glands can have intraluminal concretions that vary in color from orange to gray or green
  • May be seen underlying the urethral urothelium
  • Micro Images
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    Intraluminal concretions

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    Features of carcinoma not present

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    Tightly packed small acini

    Positive Stains
  • The immunophenotype is identical to normal prostate glands, including basal cell markers
  • Differential Diagnosis
  • Verumontanum mucosal gland hyperplasia (VMGH), when present in a prostate needle biopsy, could be mistaken for low grade prostatic adenocarcinoma (Gleason pattern 3)
  • The lobular architecture and the presence of basal cells are features to differentiate it from Gleason pattern 3 cancer
  • Another helpful feature is the presence of corpora amylacea or the orange-grey-green concretions that are features of VMGH and not of prostatic carcinoma
  • Occasionally, it can present with a papillary architecture simulating prostatic duct adenocarcinoma
  • In contrast to prostatic duct carcinoma, the cells in VMGH are more cuboidal and without nuclear atypia