Other malignancies
Yolk sac tumor

Author: Kenneth Iczkowski, M.D. (see Authors page)

Revised: 28 February 2017, last major update February 2017

Copyright: (c) 2003-2017,, Inc.

PubMed search: prostatic yolk sac tumor

See also Testes - Yolk sac tumor

Cite this page: Yolk sac tumor. website. Accessed December 15th, 2018.
Definition / general
Essential features
  • Elevation of serum alpha feto-protein; this marker is also used as an immunostain for the tumor
Case reports
  • Yolk sac tumor generally responds to chemotherapy, not radiotherapy
Microscopic (histologic) description
  • Tumor shows about a dozen different patterns of solid, microcystic and glandular structures of large polygonal hyperchromatic, pleomorphic cells
Positive stains
  • In addition to alpha feto-protein, Glypican 3 has lately been recognized as a better, artifact free marker for this tumor
  • Tumor is positive for a wide spectrum of cytokeratins