Other malignancies
Yolk sac tumor

Topic Completed: 1 February 2017

Revised: 28 February 2019

Copyright: 2003-2019,, Inc.

PubMed search: prostatic yolk sac tumor

See also: Testes - Yolk sac tumor

Kenneth A. Iczkowski, M.D.
Page views in 2018: 263
Page views in 2019 to date: 242
Cite this page: Iczkowski KA. Yolk sac tumor. website. Accessed September 24th, 2019.
Definition / general
Essential features
  • Elevation of serum alpha feto-protein; this marker is also used as an immunostain for the tumor
Case reports
  • Yolk sac tumor generally responds to chemotherapy, not radiotherapy
Microscopic (histologic) description
  • Tumor shows about a dozen different patterns of solid, microcystic and glandular structures of large polygonal hyperchromatic, pleomorphic cells
Positive stains
  • In addition to alpha feto-protein, Glypican 3 has lately been recognized as a better, artifact free marker for this tumor
  • Tumor is positive for a wide spectrum of cytokeratins
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