Salivary glands
Nonneoplastic tumors/tumor-like conditions
Adenomatous ductal hyperplasia of major / minor salivary glands


Topic Completed: 1 October 2015

Minor changes: 13 December 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Adenomatous ductal hyperplasia

Sally Tanakchi, M.D.
F. Zahra Aly, M.D., Ph.D.
Page views in 2019: 1,141
Page views in 2020 to date: 791
Cite this page: Tanakchi S Adenomatous ductal hyperplasia of major / minor salivary glands. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsADH.html. Accessed September 21st, 2020.
Definition / general
  • Incidental microscopic finding (70% incidence) during histologic examination of a salivary gland tumor
  • Predominates in male patients (3:1) in sixth decade of life
  • More frequent in parotid compared to submandibular gland (3:1)
  • Hypothesized to be a precursor lesion of salivary gland tumor, especially epithelial myoepithelial carcinoma
Microscopic (histologic) description
  • Proliferating ducts admixed with acinar cell complexes
  • Ducts are frequently lined with single layer of cells; on occasion, may have luminal and abluminal lining cells
  • Acinar cells are characterized by atrophic changes (loss of zymogen granules, decrease in cell volume) resulting in morphologic resemblance to intercalated ducts
Additional references
Back to top
Image 01 Image 02