Salivary glands
Non-neoplastic tumors and tumor-like conditions
Adenomatous ductal hyperplasia of major/minor salivary glands

Author: Sally Tanakchi, M.B.Ch.B. (see Authors page)
Editor: F. Zahra Aly, M.D., Ph.D.

Revised: 29 October 2015, last major update October 2015

Copyright: (c) 2002-2015,, Inc.

PubMed Search: Adenomatous ductal hyperplasia salivary
Definition / General
  • Incidental microscopic finding (70% incidence) during histologic examination of a salivary gland tumor
  • Predominates in male patients (3:1) in sixth decade of life
  • More frequent in parotid compared to submandibular gland (3:1)
  • Hypothesized to be a precursor lesion of salivary gland tumor especially epithelial-myoepithelial carcinoma
Micro Description
  • Proliferating ducts admixed with acinar cell complexes
  • Ducts are frequently lined with single layer of cells; on occasion, may have luminal and abluminal lining cells
  • Acinar cells are characterized by atrophic changes (loss of zymogen granules, decrease in cell volume) resulting in morphologic resemblance to intercalated ducts
Additional References