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Salivary glands


Diffuse infiltrative lymphocytosis syndrome (DILS)

Reviewers: Fatima Aly, M.D., National Cancer Institute (see Reviewers page)
Revised: 7 October 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.


● Often involves salivary glands (present in 1-6% of US HIV+ patients vs. up to 50% in Africa)
● Also affects lacrimal glands, kidney, muscle, nerve, liver, lung, GI, breast.
● Graded on 0-4 scale, 0: no infiltrate, 4: 2+ foci of 50 or more mononuclear cells in a 4-mm2 section

Micro description

● CD8+ lymphocytic infiltrate associated with HIV
● Resembles Sjogren’s syndrome, but the infiltrate is composed primarily of CD8+ cells, and salivary ductal epithelial atypia is common in the Cameroon in advanced HIV patients

Additional references

Arch Pathol Lab Med 2000;124:1773

End of Salivary Glands > Inflammation > Diffuse infiltrative lymphocytosis syndrome (DILS)

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