Diffuse infiltrative lymphocytosis syndrome
Reviewers: Fatima Aly, M.D., National Cancer Institute (see Reviewers page)
Revised: 7 October 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Often involves salivary glands (present in 1-6% of US HIV+ patients vs. up to 50% in Africa)
● Also affects lacrimal glands, kidney, muscle, nerve, liver, lung, GI, breast.
● Graded on 0-4 scale, 0: no infiltrate, 4: 2+ foci of 50 or more mononuclear cells in a 4-mm2 section
● CD8+ lymphocytic infiltrate associated with HIV
● Resembles Sjogren’s syndrome, but the infiltrate is composed primarily of CD8+ cells, and salivary ductal epithelial atypia is common in the Cameroon in advanced HIV patients
● Arch Pathol Lab Med 2000;124:1773
End of Salivary Glands > Inflammation > Diffuse infiltrative lymphocytosis syndrome
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).