Salivary glands - Granular cell tumor

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Salivary glands

Other tumors

Granular cell tumor

Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 26 January 2013, last major update September 2012
Copyright: (c) 2003-2013, Pathol2gyOutlines.com, Inc.

General
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● Granular cells (large eosinophilic cells with granular cytoplasm and small central nuclei) similar to tumors elsewhere

Clinical features
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● Usually parotid gland
● Multinodular, associated with paresis or may be painless
● Cases associated with surgical trauma may have features of traumatic neuroma

Case reports
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● 30 year old woman with parotid gland tumor (Int J Oral Maxillofac Surg 1999;28:383)
● 54 year old woman with a painless submandibular tumor (Laryngorhinootologie 2005;84:755)
● 74 year old man with submandibular tumor but no prior trauma (Arch Pathol Lab Med 2001;125:1000)
● Parotid gland tumor (Int J Surg Pathol 2008;16:213)
● Tumor arising from facial nerve trunks (Ann Diagn Pathol 1999;3:35)

Treatment
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● Complete resection

Micro description
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● Large eosinophilic cells with granular cytoplasm and small central nuclei

Micro images
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Parotid gland tumor: H&E and S100

Granular cells near nerve fascicles (arrows), S100+

Positive stains
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● PAS, S100, CD68, alpha-1-antitrypsin

Differential diagnosis
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● Acinic cell carcinoma: similar appearance at frozen section

End of Salivary glands > Other tumors > Granular cell tumor

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