Salivary glands
Epithelial / myoepithelial tumors
Lymphoepithelioma-like carcinoma

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 15 March 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Lymphoepithelioma-like carcinoma salivary

Cite this page: Handra-Luca, A. Lymphoepithelioma-like carcinoma. website. Accessed March 23rd, 2018.
Definition / general
  • Undifferentiated carcinoma common / familial in Eskimos and Chinese; presents as unilateral mass of parotid gland, submandibular gland or minor salivary glands in adults
Clinical features
  • May be associated with uterine lymphoepithelioma-like carcinoma
  • Metastases common to regional lymph nodes; distant metastases to liver, lung, bone
  • Treatment with surgery and radiotherapy; relatively good outcome (Br J Radiol 2006;79:52)
Case reports
Microscopic (histologic) description
  • Malignant epithelial islands resembling nonkeratinizing large cell carcinoma and lymphoid tissue with germinal centers
  • Occasional spindled areas
  • Often perineurial invasion
  • May have starry sky pattern, granuloma, amyloid; no benign lymphoepithelial lesion
Negative stains