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Salivary glands

Epithelial / myoepithelial tumors

Lymphoepithelioma-like carcinoma

Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 27 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Undifferentiated carcinoma common / familial in Eskimos and Chinese; presents as unilateral mass of parotid gland, submandibular gland or minor salivary glands in adults

Clinical features

● May be associated with uterine lymphoepithelioma-like carcinoma
● Metastases common to regional lymph nodes; distant metastases to liver, lung, bone
● Treatment with surgery and radiotherapy; relatively good outcome (Br J Radiol 2006;79:52)

Case reports

● 29 year old woman with submandibular gland tumor (Chin Med J (Engl) 2006;119:1315)
● 50 year old woman with EBV+, c-kit+ tumor (Head Neck 2006;28:182)

Micro description

● Malignant epithelial islands resembling nonkeratinizing large cell carcinoma and lymphoid tissue with germinal centers
● Occasional spindled areas
● Often perineurial invasion
● May have starry sky pattern, granuloma, amyloid; no benign lymphoepithelial lesion

Micro images

Diffuse lymphoid infiltration around atrophic acini of salivary gland

H&E, keratin (low/high power each)

Positive stains

● Keratin, EBV (Histopathology 1997;31:75, J Clin Pathol 1995;48:1022), c-kit, EMA, AE1

Negative stains

● AE3

End of Salivary glands > Epithelial / myoepithelial tumors > Lymphoepithelioma-like carcinoma

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