Salivary glands
Primary salivary gland neoplasms - malignant
Lymphoepithelial carcinoma


Topic Completed: 1 September 2012

Revised: 15 May 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: lymphoepithelial carcinoma salivary [title]

Adriana Handra-Luca, M.D.
Page views in 2018: 1,177
Page views in 2019 to date: 1,271
Cite this page: Handra-Luca A. Lymphoepithelial carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsLEL.html. Accessed August 20th, 2019.
Definition / general
  • Undifferentiated carcinoma common / familial in Eskimos and Chinese; presents as unilateral mass of parotid gland, submandibular gland or minor salivary glands in adults
Clinical features
  • May be associated with uterine lymphoepithelioma-like carcinoma
  • Metastases common to regional lymph nodes; distant metastases to liver, lung, bone
  • Treatment with surgery and radiotherapy; relatively good outcome (Br J Radiol 2006;79:52)
Case reports
Microscopic (histologic) description
  • Malignant epithelial islands resembling nonkeratinizing large cell carcinoma and lymphoid tissue with germinal centers
  • Occasional spindled areas
  • Often perineurial invasion
  • May have starry sky pattern, granuloma, amyloid; no benign lymphoepithelial lesion
Negative stains
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