Salivary glands
Lymphoma
MALT lymphoma

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 20 March 2018, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: MALT lymphoma[TI] salivary

Cite this page: Handra-Luca, A. MALT lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsMALT.html. Accessed July 21st, 2018.
Definition / general
  • Similar to MALT lymphoma elsewhere; low grade monocytoid B cells surround ducts and produce lymphoepithelial lesions
  • Often associated with Sjögren syndrome (Mod Pathol 2000;13:4) or benign lymphoepithelial lesion, perhaps due to chronic antigenic stimulation
Clinical features
  • Most common lymphoma of salivary glands - 3% of tumors of major salivary glands; also occur in minor salivary glands
  • Often bilateral, 30% multiglandular
  • Cystic, 1 - 6 cm (median 2 cm), with ill demarcated margins (on imaging)
  • May occur in children, posttransplantation (Am J Surg Pathol 2000;24:100), associated with Sjögren syndrome, HIV, scleroderma, sialolithiasis, Waldenström macroglobulinemia (Am J Clin Pathol 2001;116:683), Warthin tumor
  • Indolent, excellent prognosis, although 35% recur at 5 years
  • Treat with radiotherapy
Diagnosis
  • Monoclonal by immunohistochemistry or flow cytometry; monocytoid infiltrates in regional lymph nodes
  • Monoclonality in lymphoid infiltrates by PCR is insufficient for diagnosis
Case reports
Microscopic (histologic) description
  • Monocytoid cells surround ducts; low grade B cells
  • May be Helicobacter pylori positive (tumor may regress after treatment)
  • May have amyloid deposits, transformation to diffuse large B cell lymphoma
Microscopic (histologic) images

Images hosted on other servers:

Parotid gland

Positive stains
Negative stains
Molecular / cytogenetics description
4 types of translocations (some organ specificity):
  1. t(14;18)(q32;q21): IGH / MALT1 (10 - 20% of salivary gland MALT)
  2. t(11;18)(q21;q21): API2 / MALT1
  3. t(1;14)(p22;q32): BCL10 / IGH
  4. t(3;14)(p14.1;q32): FOXP1 / IGH.t

  • t(11;18)(q21;q21) is specific
  • Also DAPK methylation, A20 deletion, aneuploid
Differential diagnosis