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Salivary glands


T cell lymphoma

Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 26 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Includes adult T cell leukemia, angiocentric T cell lymphoma (associted with necrotizing sialometaplasia, Ann Diagn Pathol 2009;13:60), HTLV1 lymphoma, peripheral T cell lymphoma, T/NK cell lymphoma (with hemophagocytic syndrome)
● Very rare

Clinical features

● Parotid, submandibular gland, palate
● May occur post-transplant
● May be EBV+ (in CD56+ cases)
● Associated with Sjogren disease

Case reports

● 34 year old woman with NK cell lymphoma of parotid gland (ORL J Otorhinolaryngol Relat Spec 2003;65:219)
● 42 year old man with AIDS and parotid gland tumor with NK/T cell phenotype (Arch Pathol Lab Med 2002;126:738)
● 48 yr old woman with HTLV1 related tumor secondary to blood transfusions for menorrhagia (Diagn Cytopathol 2004;31:333)
● 58 year old man with parotid tumor mass (Pathol Int 2012;62:60)
● 66 year old man with neck and pharyngeal masses (Pathol Int 2010;60:326)
● 69 year old man with primary T cell lymphoma resembling MALT (J Clin Pathol 2002;55:61)
● Adult T cell leukemia involving bilateral parotid and submandibular glands (Eur J Haematol 2004;73:332)
● Parotid T cell lymphoma post cardiac transplant (J Oral Maxillofac Surg 2001;59:673)

Micro descriptions

● Prominent lymphoepithelial lesions similar to those in B cell lymphomas (Hum Pathol 1997;28:238); other features associated with specific diagnosis

Micro images

NK cell tumor cells with large vesicular nuclei and prominent nucleoli, CD3+, UCHL1+, TIA1+, EBER+ by ISH

Primary T cell lympoma resembling MALT

End of Salivary glands > Lymphomas > T cell lymphoma

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