Salivary glands
Epithelial / myoepithelial tumors
Adenosquamous carcinoma

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 13 March 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Adenosquamous carcinoma salivary

Cite this page: Handra-Luca, A. Adenosquamous carcinoma. website. Accessed July 22nd, 2018.
Definition / general
  • Rare, aggressive, high grade tumor with squamous and glandular components (Mod Pathol 2002;15:298)
  • In minor (but not major) salivary glands and ducts
  • > 90% males, mean age 58 years (range 32 - 99 years)
  • Symptoms: pain
  • 5 year survival: 25%
  • Metastases to lymph nodes; locoregional and distant recurrence in 70 - 80% even with primaries < 1 cm
  • Tongue, floor of mouth, nasal cavity, larynx, upper lip, palate, upper and lower alveoli
  • Surgical resection with neck dissection, radiotherapy
Gross description
  • 2 mm to 1 cm erythroplakic ulcer or indurated submucosal nodule
Microscopic (histologic) description
  • Variable histology
  • Adenocarcinoma, squamous cell carcinoma and mixtures resembling mucoepidermoid carcinoma
  • Adjacent tumors may cause multifocal carcinoma in situ involving salivary gland ducts, upward extension of intraductal carcinoma to involve mucosal epithelium, glassy squamous cells (Eur Arch Otorhinolaryngol 2003;260:509)
  • Commonly perineurial invasion and widespread invasion of submucosa
Positive stains
Negative stains
Molecular / cytogenetics description
Differential diagnosis