Salivary glands
Primary salivary gland neoplasms - malignant
Adenosquamous carcinoma

Topic Completed: 1 September 2012

Revised: 30 April 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Adenosquamous carcinoma salivary

Adriana Handra-Luca, M.D.
Page views in 2018: 1,423
Page views in 2019 to date: 1,590
Cite this page: Handra-Luca A. Adenosquamous carcinoma. website. Accessed October 22nd, 2019.
Definition / general
  • Rare, aggressive, high grade tumor with squamous and glandular components (Mod Pathol 2002;15:298)
  • In minor (but not major) salivary glands and ducts
  • > 90% males, mean age 58 years (range 32 - 99 years)
  • Symptoms: pain
  • 5 year survival: 25%
  • Metastases to lymph nodes; locoregional and distant recurrence in 70 - 80% even with primaries < 1 cm
  • Tongue, floor of mouth, nasal cavity, larynx, upper lip, palate, upper and lower alveoli
  • Surgical resection with neck dissection, radiotherapy
Gross description
  • 2 mm to 1 cm erythroplakic ulcer or indurated submucosal nodule
Microscopic (histologic) description
  • Variable histology
  • Adenocarcinoma, squamous cell carcinoma and mixtures resembling mucoepidermoid carcinoma
  • Adjacent tumors may cause multifocal carcinoma in situ involving salivary gland ducts, upward extension of intraductal carcinoma to involve mucosal epithelium, glassy squamous cells (Eur Arch Otorhinolaryngol 2003;260:509)
  • Commonly perineurial invasion and widespread invasion of submucosa
Positive stains
Negative stains
Molecular / cytogenetics description
Differential diagnosis
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