Salivary glands
Non-neoplastic tumors and tumor-like conditions

Author: Sally Tanakchi, M.B.Ch.B. (see Authors page)
Editor: F. Zahra Aly, M.D., Ph.D.

Revised: 30 October 2015, last major update October 2015

Copyright: (c) 2002-2015,, Inc.

PubMed Search: Amyloidosis [title] salivary
Cite this page: Amyloidosis. website. Accessed February 19th, 2018.
Definition / general
  • Amyloidosis can develop either as a local or systemic disease
  • In head and neck region, the larynx is most common site of involvement
  • Salivary gland amyloidosis is usually secondary and involves a minor salivary gland
  • Involvement of a major salivary gland by amyloidosis is very rare
    • Symptoms of involvement can mimic Sjogren syndrome
  • Biopsy of minor salivary gland (labial gland) is recommended to demonstrate systemic amyloidosis, with a sensitivity of 60 - 100%
Case reports
Microscopic (histologic) description
  • The gold standard to diagnose amyloidosis is demonstration of Congo Red positivity with apple green birefringence on polarization
  • Positivity for amyloid A or amyloid P antibody staining is used for classification
Microscopic (histologic) images
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Labial salivary gland

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Congo Red, gingiva

Additional references