Salivary glands
Nonneoplastic tumors and tumor-like conditions

Author: Sally Tanakchi (see Authors page)
Editor: F. Zahra Aly, M.D., Ph.D.

Revised: 12 March 2018, last major update October 2015

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Amyloidosis[TI] salivary
Cite this page: Tanakchi, S. Amyloidosis. website. Accessed June 21st, 2018.
Definition / general
  • Amyloidosis can develop either as a local or systemic disease
  • In head and neck region, the larynx is most common site of involvement
  • Salivary gland amyloidosis is usually secondary and involves a minor salivary gland
  • Involvement of a major salivary gland by amyloidosis is very rare
    • Symptoms of involvement can mimic Sjögren syndrome
  • Biopsy of minor salivary gland (labial gland) is recommended to demonstrate systemic amyloidosis, with a sensitivity of 60 - 100%
Case reports
Microscopic (histologic) description
  • Gold standard to diagnose amyloidosis is demonstration of Congo red positivity with apple green birefringence on polarization
  • Positivity for amyloid A or amyloid P antibody staining is used for classification
Microscopic (histologic) images

Images hosted on other servers:
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Labial salivary gland

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Congo red, gingiva

Additional references