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Salivary glands



Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 24 January 2014, last major update September 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.


● Rare in salivary glands (only 4% of all angiosarcomas), usually parotid (primary or secondary) or submandibular gland (primary)
● Mean age 55 years
● No gender prevalence
● Often relatively good outcome at this site, even with high grade features (Mod Pathol 2003;16:263, Cancer 1986;58:1305)

Case reports

● 17 year old boy with one year history of slow growing, tender submandibular mass (Acta Otolaryngol 2003;123:440)
● 77 year old woman with poorly differentiated tumor (Cesk Patol 2009;45:69)
● Arising from congenital hemangioma of parotid gland (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003;96:66)

Micro description

● Usually spindled cells with solid or vasoformative growth pattern, often epithelioid (28%)
● May have low, intermediate or high grade features
● May occur in congenital hemangioma

Micro images

Various images (primary and secondary tumors)

Positive stains

● CD31, CD34, EMA, factor VIII, Ulex

End of Salivary glands > Sarcomas > Angiosarcoma

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