Non-neoplastic tumors and tumor-like conditions
Benign lymphoepithelial cysts
Reviewers: Fatima Aly, M.D. (see Reviewers page)
Revised: 1 February 2013, last major update August 2011
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Often older women with Sjogrenís syndrome and autoantibodies
● Probably derives from salivary gland epithelium inclusion within a lymph node or from epithelium which induces a reactive lymphoid hyperplasia
● Parotid gland or upper cervical lymph nodes
● May be related to branchial cleft cyst, multilocular thymic cyst, Warthinís tumor
● Usually unilocular but may be multilocular
● Cyst lined by glandular or squamous epithelium and surrounded by prominent lymphoid follicles with CD4+ cells, which may penetrate cyst lining
● Benign lymphoepithelial lesion, keratinous cyst (no associated lymphoid infiltrate), Warthinís tumor (2 layers of oncocytic cells), low grade mucoepidermoid carcinoma (complex hyperplastic epithelium with mucinous cells), true branchial cleft cyst (presence of accompanying sinus tract or stalk)
HIV associated lymphoepithelial cyst
● Resembles benign lymphoepithelial cyst
● Common in young individuals with HIV and usually involves the parotid gland
● Cyst epithelium derives from striated ducts
● Lymphocytes are polyclonal, CD8+
● Usually doesnít progress to lymphoma
● In children, lesions may be monoclonal and resemble MALT but donít progress to MALT lymphoma
● Lymphocytes may have clear cytoplasm and penetrate epithelium
End of Salivary Glands > Non-neoplastic tumors and tumor-like conditions > Benign lymphoepithelial cysts
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