Salivary glands
Primary salivary gland neoplasms - malignant
Basal cell adenocarcinoma


Topic Completed: 1 September 2012

Revised: 30 April 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Basal cell adenocarcinoma[TI] salivary

Adriana Handra-Luca, M.D.
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Cite this page: Handra-Luca A. Basal cell adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsbasalcelladenocarcinoma.html. Accessed October 22nd, 2019.
Definition / general
  • Low grade malignant counterpart of basal cell adenoma; infiltrative with perineurial invasion and vascular invasion (Mod Pathol 2002;15:298)
  • Also called basaloid carcinoma
Clinical features
  • 1 - 2% of salivary gland carcinomas
  • Malignant counterpart of basal cell adenoma - 23% arise within preexisting basal cell adenomas
  • Associated with dermal cylindromas
  • Slow growing
  • Usually parotid gland, adults, ages 50+, also in minor salivary glands
  • No gender predilection
  • Locally destructive
  • 37% recur locally, 8% metastasize (solid pattern) to lymph nodes, 4% to lungs but death from disease is unusual
Treatment
Gross images

Images hosted on other servers:

Bisected specimen with focal hemorrhage

Microscopic (histologic) description
  • Low grade malignancy similar to basal cell adenoma but infiltrative with perineurial invasion and vascular invasion
  • Multicentric, variable cytologic atypia and mitotic activity
  • Two cell types: small cells with scant cytoplasm and dark nuclei (may show palisading pattern) and polygonal cells with eosinophilic / amphophilic cytoplasm and clear nuclei
  • Patterns: solid, trabecular, tubular, membranous
  • No myxoid matrix, no cyst formation
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Differential diagnosis
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