Salivary glands
Primary salivary gland neoplasms - benign
Basal cell adenoma


Topic Completed: 1 September 2012

Revised: 17 May 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Basal cell adenoma[TI] salivary gland

See also: Dermal analogue tumor

Adriana Handra-Luca, M.D.
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Cite this page: Handra-Luca A. Basal cell adenoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsbasalcelladenoma.html. Accessed September 23rd, 2019.
Definition / general
  • Benign tumor resembling pleomorphic adenoma but with basaloid cells and peripheral palisading
  • First described by Kleinasser and Klein in 1967
  • Also called monomorphic adenoma; excludes canalicular adenoma
Clinical features
  • 1 - 2% of epithelial tumors of salivary glands; 2% of benign salivary gland tumors
  • Solitary or part of turban tumor, Brooke-Spiegler syndrome
  • Usually adults, 2/3 female, mean age 58 years
  • Rarely is congenital and resembles embryoma
  • Parotid gland or periparotid lymph nodes
  • Low recurrence rate
  • Rarely transforms; more likely if dermal analogue variant (4% malignant transformation)
  • Usually some myoepithelial differentiation using immunostains (Arch Pathol Lab Med 2000;124:401)
Treatment
  • Excision
Case reports
Gross description
  • Encapsulated, often cystic, relatively small
Gross images

Case of the Week #375
Microscopic (histologic) description
  • Solid, trabecular, trabecular-tubular, membranous or tubular growth of epithelial cells (morphological types) resembling pleomorphic adenoma but with peripheral palisading (Mod Pathol 2002;15:298)
  • Basaloid cells, bland cytology, occasional peripheral palisading
  • Fibrous stroma present
  • Occasionally has acinar cells, squamous whorls or keratinization
  • No invasion, no mesenchymal component, no perineurial invasion, no myxoid matrix, no cystic change
Microscopic (histologic) images

Case of the Week #375

Various images



Images hosted on other servers:

Various images

Figure 5A

Cytology images

Case of the Week #375

Various images

Positive stains
Dermal analogue tumor
Definition / general
  • Uncommon subtype of basal cell monomorphic adenoma with clinical and histological resemblance to dermal cylindroma
  • First described in 1974 by Drut and in 1977 by Headington and Reingold (Cancer 1977;39:2460, Cancer 1977;40:1702)
  • Also called membranous tumor

Clinical features
  • Usually in parotid gland or intranodal parotid gland, ectopic salivary gland in lymph nodes (periparotid, cervical, Cancer 1987;59:1165)
  • Sporadic or familial
  • Histogenesis: germinal epithelium of ectodermal origin
  • Usually men, mean age 60 years old
  • 25 - 38% have cutaneous tumors
  • Occasionally coexists with multiple dermal cylindromas (Brooke-Spiegler syndrome, autosomal dominant salivary gland - skin adnexal tumor syndrome, Head Neck 2010;32:684), Warthin tumor
  • Multicentricity and multiple recurrencies
  • Long period of followup required
  • Treat with resection but 25 - 37% recur, 28% undergo malignant transformation to basaloid adenocarcinoma with destructive infiltrative growth beyond gland margins and perineurial or vascular invasion but not necessarily pleomorphism, necrosis or mitotic activity

Gross description
  • Usually unencapsulated, 50% multifocal, up to 3.5 cm

Cytology description
Positive stains
Molecular / cytogenetics description
Differential diagnosis
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