Salivary glands
Epithelial / myoepithelial tumors
Basal cell adenoma

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 13 March 2018, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Basal cell adenoma[TI] salivary gland

See also: Dermal analogue tumor
Cite this page: Handra-Luca, A. Basal cell adenoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsbasalcelladenoma.html. Accessed December 16th, 2018.
Definition / general
  • Benign tumor resembling pleomorphic adenoma but with basaloid cells and peripheral palisading
  • First described by Kleinasser and Klein in 1967
  • Also called monomorphic adenoma; excludes canalicular adenoma
Clinical features
  • 1 - 2% of epithelial tumors of salivary glands; 2% of benign salivary gland tumors
  • Solitary or part of turban tumor, Brooke-Spiegler syndrome
  • Usually adults, 2/3 female, mean age 58 years
  • Rarely is congenital and resembles embryoma
  • Parotid gland or periparotid lymph nodes
  • Low recurrence rate
  • Rarely transforms; more likely if dermal analogue variant (4% malignant transformation)
  • Usually some myoepithelial differentiation using immunostains (Arch Pathol Lab Med 2000;124:401)
Treatment
  • Excision
Case reports
Gross description
  • Encapsulated, often cystic, relatively small
Gross images

Images hosted on PathOut server:

Case of the Week #375:
Microscopic (histologic) description
  • Solid, trabecular, trabecular-tubular, membranous or tubular growth of epithelial cells (morphological types) resembling pleomorphic adenoma but with peripheral palisading (Mod Pathol 2002;15:298)
  • Basaloid cells, bland cytology, occasional peripheral palisading
  • Fibrous stroma present
  • Occasionally has acinar cells, squamous whorls or keratinization
  • No invasion, no mesenchymal component, no perineurial invasion, no myxoid matrix, no cystic change
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #375:

Various images



Images hosted on other servers:

Various images

Figure 5A

Cytology images

Images hosted on PathOut server:

Case of the Week #375:

Various images

Positive stains