Salivary glands
Epithelial / myoepithelial tumors
Basal cell adenoma

Reviewer: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 6 January 2016, last major update September 2012

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PubMed Search: Basal cell adenoma salivary gland

Related: Dermal analogue tumor
Cite this page: Basal cell adenoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsbasalcelladenoma.html. Accessed December 3rd, 2016.
Definition / General
  • Benign tumor resembling pleomorphic adenoma but with basaloid cells and peripheral palisading
  • First described by Kleinasser and Klein in 1967
  • Also called monomorphic adenoma; excludes canalicular adenoma
Clinical Features
  • 1-2% of epithelial tumors of salivary glands; 2% of benign salivary gland tumors
  • Solitary, or part of Turban tumor Brooke-Spiegler syndrome
  • Usually adults, 2/3 female, mean age 58 years
  • Rarely is congenital and resembles embryoma
  • Parotid gland or periparotid lymph nodes
  • Low recurrence rate
  • Rarely transforms; more likely if dermal analogue variant, (4% malignant transformation)
  • Usually some myoepithelial differentiation using immunostains (Arch Pathol Lab Med 2000;124:401)
Treatment
  • Excision
Case Reports
Gross Description
  • Encapsulated, often cystic, relatively small
Gross Images

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Case of the Week #375

Micro Description
  • Solid, trabecular, trabecular-tubular, membranous or tubular growth of epithelial cells (morphological types) resembling pleomorphic adenoma but with peripheral palisading (Mod Pathol 2002;15:298)
  • Basaloid cells, bland cytology, occasional peripheral palisading
  • Fibrous stroma present
  • Occasionally has acinar cells, squamous whorls or keratinization
  • No invasion, no mesenchymal component, no perineurial invasion, no myxoid matrix, no cystic change
Micro Images

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Case of the Week #375




Images hosted on other servers:

Various images

Figure 5A

Morphologic variants

Calponin+ myoepithelial differentiation

Cytology Images

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Case of the Week #375




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Positive Stains
  • Ductal cells: keratin, alpha-1-antichymotrypsin, CEA, S100 (alpha subunit)
  • Basaloid cells: vimentin, actin, S100 (beta subunit)
  • Also IL6 (Hum Pathol 1995;26:501)