Salivary glands
Benign metastasizing mixed tumors

Topic Completed: 1 September 2012

Minor changes: 12 March 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Benign metastasizing mixed tumor salivary gland

See Also: Pleomorphic adenoma

Adriana Handra-Luca, M.D.
Page views in 2019: 236
Page views in 2020 to date: 153
Cite this page: Handra-Luca A. Benign metastasizing mixed tumors. website. Accessed October 21st, 2020.
Definition / general
  • Controversial but distinctive clinical entity with late metastasis (6 - 52 years) after tumor excision to bone, CNS, kidney, liver, lung, lymph nodes, maxilla, pharynx, skin, sphenoid sinus; benign morphology in original and metastatic tumor
  • Some limit diagnosis to cases in which metastasis is identical to salivary gland pleomorphic adenoma
  • Rare, < 50 cases reported
  • 24% are incidental findings
  • Mean age 33 years
  • Associated with incomplete pleomorphic adenoma surgery / local recurrence, post cardiac transplant patient / immunosuppression (Mod Pathol 1998;11:1142)
  • 5 year disease specific and disease free survivals of 58 and 50%
  • Metastasis thought to occur via vascular channels due to tumor fragmentation or seeding at surgery
  • Possible predictive features of metastatic behavior: mitoses, infiltrative growth pattern, myoepithelial cell proliferation
Case reports
Microscopic (histologic) images

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Sphenoid sinus metastasis from palate

Spinal cord
metastasis from
tumor (MRI, H&E)

Positive stains
Molecular / cytogenetics description
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