Salivary glands
Cytopathology competency / milestone assessment
6. Benign salivary gland tumors

Authors: Michelle R. Pramick, M.D., Zubair W. Baloch, M.D., Ph.D. (see Authors page)

Revised: 12 March 2018, last major update December 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Benign salivary gland tumors[TIAB]

Cite this page: Pramick, M.R., Baloch, Z.W. Cytopathology competency - 6. benign salivary gland tumors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandscompbenigntumors.html. Accessed October 16th, 2018.
Pleomorphic adenoma (benign mixed tumor)
Medical knowledge:
  1. Understand the clinical characteristics, presentation and prognosis of pleomorphic adenoma
  2. Recognize the variable architectural arrangements, cellular and noncellular components and key nuclear and cytoplasmic features of pleomorphic adenoma in an aspirate biopsy
  3. Understand that pleomorphic adenoma can undergo malignant degeneration
  4. Know the differential diagnosis of pleomorphic adenoma and the key features to differentiate these neoplasms
  5. Identify the characteristic metachromatic stroma of pleomorphic adenoma on a Diff-Quik stained slide (usually transparent on a Papanicolaou stained slide)

Practice based learning:
  1. Know that pleomorphic adenomas are prone to recur if not adequately excised (due to small finger-like projections); cannot be enucleated
  2. Know the clinical presentation of malignant degeneration of a pleomorphic adenoma
Monomorphic adenomas
Medical knowledge:
  1. Understand the clinical characteristics, presentation and prognosis of monomorphic adenomas
  2. Know the various types of monomorphic adenomas and recognize the architectural arrangements and key nuclear and cytoplasmic features of each type of monomorphic adenoma in an aspirate biopsy:
    • Basal cell adenoma
    • Trabecular adenoma
    • Tubular adenoma
    • Canalicular adenoma
    • Clear cell adenoma
    • Sebaceous adenoma
    • Myoepithelioma
  3. Know the differential diagnosis of each type of monomorphic adenoma and the key features to differentiate these lesions
  4. Understand the differential diagnosis of entities where sebaceous cells can be seen (neoplasms and normal)
  5. Know that myoepithelioma tends to be more aggressive and may convert to malignant myoepithelioma
Warthin tumor (papillary cystadenoma lymphomatosum)
Medical knowledge:
  1. Understand the clinical characteristics, presentation and prognosis of Warthin tumor
  2. Recognize the architectural arrangements, cellular and noncellular components and key nuclear and cytoplasmic features of Warthin tumor in an aspirate biopsy
  3. Know the differential diagnosis of Warthin tumor and the key features to differentiate these entities
Oncocytoma
Medical knowledge:
  1. Understand the clinical characteristics, presentation and prognosis of oncocytoma
  2. Recognize the architectural arrangements, cellular components and key nuclear and cytoplasmic features of oncocytoma in an aspirate biopsy
  3. Understand that oncocytoma may display marked cytologic atypia and oncocytic carcinoma may have benign appearing cells, therefore evidence of invasion or metastasis provides definitive proof of malignancy
  4. Know the differential diagnosis of oncocytoma and the key features to differentiate these entities