Salivary glands
Cytopathology competency / milestone assessment
7. Malignant salivary gland tumors

Authors: Michelle R. Pramick, M.D., Zubair W. Baloch, M.D., Ph.D. (see Authors page)

Revised: 12 March 2018, last major update December 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Malignant salivary gland tumors[TI]

Cite this page: Pramick, M.R., Baloch, Z.W. Cytopathology competency - 7. malignant salivary gland tumors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandscompmalignanttumors.html. Accessed November 17th, 2018.
Adenoid cystic carcinoma
Medical knowledge:
  1. Understand the clinical characteristics, presentation and prognosis of adenoid cystic carcinoma
  2. Recognize the architectural arrangements and key nuclear and cytoplasmic features of adenoid cystic carcinoma in an aspirate biopsy
  3. Understand that adenoid cystic carcinoma can dedifferentiate into a high grade lesion with anaplastic cytology
  4. Know the differential diagnosis of neoplasms in which hyaline globules can be seen
  5. Know the differential diagnosis of adenoid cystic carcinoma and the key features to differentiate these neoplasms
Mucoepidermoid carcinoma
Medical knowledge:
  1. Understand the clinical characteristics, presentation and prognosis of mucoepidermoid carcinoma
  2. Recognize the cellular components and key nuclear and cytoplasmic features of mucoepidermoid carcinoma in an aspirate biopsy
  3. Understand the clinical and prognostic significance of a low grade mucoepidermoid carcinoma compared to a high grade mucoepidermoid carcinoma
  4. Recognize the key findings seen in an aspirate biopsy to differentiate a low grade from a high grade mucoepidermoid carcinoma
  5. Know the differential diagnosis of mucoepidermoid carcinoma and the key features to differentiate these neoplasms
Acinic cell carcinoma
Medical knowledge:
  1. Understand the clinical characteristics, presentation and prognosis of acinic cell carcinoma
  2. Recognize the cellular components (present and absent) and key nuclear and cytoplasmic features of acinic cell carcinoma in an aspirate biopsy
  3. Know the differential diagnosis of acinic cell carcinoma and the key features to differentiate these entities (including benign salivary gland)

Practice based learning:
  1. Know that the cytoplasmic zymogen granules in acinic cells are PAS positive
Malignant mixed tumor
Medical knowledge:
  1. Know the 3 categories of malignant mixed tumors
    • Carcinoma ex pleomorphic adenoma
    • True malignant mixed tumor (carcinosarcoma)
    • Benign metastasizing mixed tumor
  2. Understand the clinical characteristics, presentation and prognosis of each type of malignant mixed tumor
  3. Recognize the cellular components, architectural arrangement and key nuclear and cytoplasmic features each type of malignant mixed tumor in an aspirate biopsy
  4. Know the differential diagnosis of each type of malignant mixed tumor and the key features to differentiate these entities