Salivary glands
Cytopathology competency / milestone assessment
8. Other salivary gland tumors

Authors: Michelle R. Pramick, M.D., Zubair W. Baloch, M.D., Ph.D. (see Authors page)

Revised: 12 March 2018, last major update December 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Other salivary gland tumors[TIAB]

Cite this page: Pramick, M.R., Baloch, Z.W. Cytopathology competency - 8. other salivary gland tumors. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandscompothertumors.html. Accessed July 21st, 2018.
Adenocarcinomas
Medical knowledge:
  1. Understand that this category includes adenocarcinomas of the salivary gland that do not fit into other recognized entities
  2. Recognize the cellular components, architectural arrangement and key nuclear and cytoplasmic features of adenocarcinomas present in salivary gland tissue
    • Mucous producing carcinoma
    • Papillary adenocarcinoma
    • Salivary duct carcinoma
    • Polymorphous low grade carcinoma
    • Epithelial-myoepithelial carcinoma
    • Basal cell adenocarcinoma
  3. Understand the clinical characteristics, presentation and prognosis of each of these malignancies
  4. Know the differential diagnosis of each of these malignancies and the key features to differentiate these entities
Primary squamous cell carcinoma
Medical knowledge:
  1. Understand the clinical characteristics, presentation and prognosis of squamous cell carcinoma
  2. Recognize the architectural arrangements and key nuclear and cytoplasmic features of squamous cell carcinoma in an aspirate biopsy
  3. Know the differential diagnosis of squamous cell carcinoma and the key features to differentiate these entities

Practice based learning:
  1. Understand that metastatic squamous cell carcinoma is more common than primary squamous cell carcinoma
Undifferentiated carcinoma
Medical knowledge:
  1. Recognize that undifferentiated carcinoma is a subtype of salivary gland carcinoma with lymphoid stroma
  2. Understand the clinical characteristics, presentation and prognosis of undifferentiated carcinoma
  3. Know that undifferentiated carcinoma is associated with Epstein-Barr virus
  4. Recognize the cellular components, architectural arrangements and key nuclear and cytoplasmic features of undifferentiated carcinoma in an aspirate biopsy
  5. Know the differential diagnosis of undifferentiated carcinoma and the key features to differentiate these entities
Small cell carcinoma
Medical knowledge:
  1. Understand that small cell carcinoma is a type of nonpulmonary poorly differentiated neuroendocrine carcinoma
  2. Understand the clinical characteristics, presentation and prognosis of small cell carcinoma
  3. Recognize the cellular components, architectural arrangements and key nuclear and cytoplasmic features of small cell carcinoma in an aspirate biopsy
  4. Know the differential diagnosis of small cell carcinoma and the key features to differentiate these neoplasms
Malignant myoepithelioma
Medical knowledge:
  1. Know that the key characteristics that differentiate malignant myoepithelioma from myoepithelioma
  2. Understand the clinical characteristics, presentation and prognosis of malignant myoepithelioma
Clear cell tumors
Medical knowledge:
  1. Understand that clear cell tumors can be benign or malignant
    • Myoepithelial adenoma / carcinoma
    • Acinic cell carcinoma
    • Mucoepidermoid carcinoma
    • Sebaceous neoplasms
    • Oncocytomas
    • Metastatic carcinoma (frequently renal)
  2. Understand the clinical characteristics, presentation and prognosis of clear cell tumors
  3. Recognize the cellular components, architectural arrangements and key nuclear and cytoplasmic features of each type of clear cell tumor in an aspirate biopsy
  4. Know the differential diagnosis of each clear cell tumor and the key features to differentiate these entities
Malignant lymphoma
Medical knowledge:
  1. Understand the clinical characteristics, presentation and prognosis of lymphoma
  2. Recognize the cellular components, architectural arrangements and key nuclear and cytoplasmic features of lymphoma in an aspirate biopsy
  3. Know the differential diagnosis of lymphoma and the key features to differentiate these entities

Practice based learning:
  1. Recognize that when lymphoma is suspected, a portion of the aspirate should be sent for flow cytometric analysis
Mesenchymal tumors
Medical knowledge:
  1. Understand the clinical characteristics, presentation and prognosis of mesenchymal tumors
    • Hemangioma
    • Neurofibroma
    • Schwannoma
    • Hemangiopericytoma
  2. Recognize the cellular components, architectural arrangements and key nuclear and cytoplasmic features each type of salivary gland mesenchymal tumor in an aspirate biopsy
  3. Know the differential diagnosis of each type of salivary gland mesenchymal tumor and the key features to differentiate these entities
Metastasis
Medical knowledge:
  1. Know the most frequent types of metastasis to an intraparotid lymph node
    • Squamous cell carcinoma
    • Melanoma
  2. Know the most common primary sites for hematogenous metastasis
    • Lung
    • Kidney
    • Breast
  3. Recognize the cellular components, architectural arrangements and key nuclear and cytoplasmic features metastatic lesions to salivary glands in an aspirate biopsy
  4. Know the differential diagnosis of each type of these entities and the key features to differentiate these lesions from primary salivary gland neoplasms