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Salivary glands

Other tumors


Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 27 January 2013, last major update September 2012
Copyright: (c) 2003-2013, Pathol2gyOutlines.com, Inc.


● Rare malignant tumor, diagnosed at or near birth, resembling epithelial anlage of salivary glands but in arrested state of differentiation (Ann Otol Rhinol Laryngol 1992;101:958, Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109:109)
● Also called sialoblastoma

Clinical features

● Childhood epithelial salivary gland tumor; common among the perinatal tumors
● Occurs in submandibular, parotid or minor salivary glands; also ectopic salivary gland tissue
● Uni- or multinodular, 2-7 cm, rapid growth
● May recur locally or involve regional lymph nodes; also lung metastases

Case reports

● Female infant with tumor arising in ectopic salivary gland tissue in cheek (J Plast Reconstr Aesthet Surg 2009;62:e241)
● Male infant with congenital tumor arising in minor salivary gland of buccal mucosa (Fetal Pediatr Pathol 2011;30:32)
● 3 month old boy with submandibular swelling of insidious onset (J Pediatr Surg 2008;43:e11)
● 3 month old girl with recurrent and metastatic tumor (Rare Tumors 2011;3:e13)
● 18 month old girl with parotid gland tumor (Pediatr Blood Cancer 2010;55:1427)
● 2 year old old with 2 cm mass in parotid gland with increasing anaplasia (Am J Surg Pathol 1999;23:342)
● 6 year old girl with recurrent tumor (Acta Cytol 2003;47:1123)


● Excision; chemotherapy if cannot completely excise (Pediatr Blood Cancer 2010;55:374); possibly brachytherapy

Micro description

● Ductules and solid organoid nests of basaloid cells with fine chromatin and cuboidal epithelial cells
● 2 histological patterns: favorable pattern with semiencapsulation of benign basaloid cells with intervening stroma; unfavorable pattern with anaplastic basaloid cells, broad pushing to infiltrative periphery and minimal stroma (Ann Diagn Pathol 2006;10:320)
● Variable necrosis, variable mitotic activity, variable nuclear atypia, no perineurial invasion

Micro images

One year old boy with parotid tumor

Recurrent and metastatic tumor

Nests of basaloid cells with poorly demarcated eosinophilic cytoplasm and round, vesicular nuclei

Cytology description

● Tight, solid clusters of atypical basaloid cells plus dispersed epithelial and myoepithelial cells with metachromatic magenta hyaline globular material

Positive stains

● Cytokeratin (ductal structures), S100, smooth muscle actin, calponin, p63
● Also AFP, cytoplasmic HER2, p53; Ki67 index increases with recurrence and may predict behavior (Pediatr Dev Pathol 2010;13:32)

Differential diagnosis

Adenoid cystic carcinoma
Basal cell adenoma
Pleomorphic adenoma: may have embryonal structures
● Teratoma

End of Salivary glands > Other tumors > Embryoma

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