Salivary glands
Nonneoplastic tumors and tumor-like conditions
Epidermoid cyst

Author: Sally Tanakchi (see Authors page)
Editor: F. Zahra Aly, M.D., Ph.D.

Revised: 13 March 2018, last major update October 2015

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Epidermoid cyst salivary
Cite this page: Tanakchi, S. Epidermoid cyst. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandsepidermoidcyst.html. Accessed June 20th, 2018.
Definition / general
  • Very rare in salivary glands with few reports of involvement of major salivary glands
  • Histogenesis thought to be ectodermal and derived from remnants of branchial pouch epithelium
  • Since easily mistaken for salivary gland abscess, neoplasm or other cysts, excision required for diagnosis and treatment
Case reports
Clinical images

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No surface discharge

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Mobility in teeth

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Salivary gland swelling

Gross images

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Globular mass

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Parotidectomy specimen

Microscopic (histologic) description
  • Unilocular cyst with squamous lining containing a granular layer, usually filled with cheesy material or keratin
Microscopic (histologic) images

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Stratified squamous epithelium

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Mature squamous cells

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Parotid acini