Salivary glands

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 20 March 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Hemangioendothelioma salivary

Cite this page: Handra-Luca, A. Hemangioendothelioma. website. Accessed November 21st, 2018.
Definition / general
  • Vascular tumor of anastomosing thin walled capillaries growing between salivary ducts and acini
  • Also called juvenile hemangioma
  • Most common salivary gland tumor of infants / children
Clinical features
  • Often congenital, involves parotid gland, submandibular gland; more common in females
  • Not malignant; intermediate behavior between angioma and angiosarcoma
  • May be associated with Kasabach-Merritt syndrome
  • 70 - 95% regress spontaneously by age 7 years
  • Fine needle aspiration may be useful for diagnosis (Arch Pathol Lab Med 2001;125:1340)
Case reports
  • Delay excision in hope of spontaneous regression; postoperative radiotherapy
Gross description
  • Diffuse soft mass uninvolved with overlying skin
  • Periglandular muscular extension
Microscopic (histologic) description
  • Anastomosing thin walled capillaries growing between salivary ducts and acini
  • Variable mitotic figures, epithelioid or Kaposiform patterns, microcalcifications
Microscopic (histologic) images

Images hosted on PathOut server:

Case of the Week #77:

Thigh mass

Cytology description
  • Spindle shaped cells in sheets and clusters in bloody background
  • Cell block shows ductal structures trapped in sheets of spindle cells
Cytology images

Images hosted on other servers:

Hypercellular clusters of
bland spindle cells surrounding
ductal structures in cell block,
factor VIII+, CD34+

Positive stains
Differential diagnosis