Salivary glands
Primary salivary gland neoplasms - malignant
Hybrid carcinoma

Topic Completed: 1 September 2012

Revised: 30 April 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Hybrid carcinoma salivary

Adriana Handra-Luca, M.D.
Page views in 2018: 403
Page views in 2019 to date: 394
Cite this page: Handra-Luca A. Hybrid carcinoma. website. Accessed October 19th, 2019.
Definition / general
  • Rare; 2+ distinct tumors in same topographic area, each at least 10% of total volume, producing a single clinical and macroscopic tumor mass (Eur J Cancer B Oral Oncol 1996;32B:251)
  • Includes masses with a benign tumor component
  • Often epithelial myoepithelial carcinoma as one of the tumors
  • 0.4% of salivary gland tumors in one series (Mod Pathol 2002;15:724)
Clinical features
  • Mean age 53 - 62 years, range 28 - 81 years
  • Usually parotid gland, 0.4% parotid tumors (less than 20 cases reported), submandibular gland, palate
  • May have cervical lymph node metastases, distant metastases
  • Must sample thoroughly since only one component may be aggressive, prognosis based on most aggressive component (Arch Pathol Lab Med 1999;123:698, Eur Arch Otorhinolaryngol 2003;260:312)
Case reports
  • Surgery, radiotherapy
Microscopic (histologic) description
  • Two or more distinct tumors in same topographic area, minor component should be at least 10% of the tumor
Microscopic (histologic) images

Images hosted on other servers:

Various tumors

Cytology description
  • Features suggestive of both tumor types
Differential diagnosis
  • Biphasic tumors
  • Collision tumors: distinct masses that meet
  • Dedifferentiated tumors / tumors with high grade transformation
  • Recurrent tumor
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