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Salivary glands

Epithelial / myoepithelial tumors

Hybrid carcinoma

Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 27 January 2013, last major update September 2012
Copyright: (c) 2003-2013, Pathol2gyOutlines.com, Inc.

General
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● Rare; 2+ distinct tumors in same topographic area, each at least 10% of total volume, producing a single clinical and macroscopic tumor mass (Eur J Cancer B Oral Oncol 1996;32B:251)
● Includes masses with a benign tumor component
● Often epithelial-myoepithelial carcinoma as one of the tumors
● 0.4% of salivary gland tumors in one series (Mod Pathol 2002;15:724)

Clinical features
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● Mean age 53-62 years, range 28-81 years
● Usually parotid gland, 0.4% parotid tumors (less than 20 cases reported), submandibular gland, palate
● May have cervical lymph node metastases, distant metastases
● Must sample thoroughly since only one component may be aggressive, prognosis based on most aggressive component (Arch Pathol Lab Med 1999;123:698, Eur Arch Otorhinolaryngol 2003;260:312)

Case reports
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● Congenital hybrid basal cell adenoma-adenoid cystic carcinoma (Pediatr Pathol 1986;6:199)
● Two young children with hybrid basal cell adenoma-adenoid cystic carcinoma (Pathology 1990;22:187)

Treatment
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● Surgery, radiotherapy

Micro description
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● Two or more distinct tumors in same topographic area, minor component should be at least 10% of the tumor

Micro images
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Figures A/B: epithelial-myoepithelioma carcinoma and basal cell adenocarcinoma

   
Various tumors

Cytology description
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● Features suggestive of both tumor types

Electron microscopy images
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Salivary duct carcinoma and squamous cell carcinoma components

Differential diagnosis
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● Biphasic tumors
● Collision tumors: distinct masses that meet
● Dedifferentiated tumors / tumors with high grade transformation
● Recurrent tumor

End of Salivary glands > Epithelial / myoepithelial tumors > Hybrid carcinoma

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