Salivary glands
Epithelial / myoepithelial tumors
Hybrid carcinoma

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 14 March 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Hybrid carcinoma salivary

Cite this page: Handra-Luca, A. Hybrid carcinoma. website. Accessed December 13th, 2018.
Definition / general
  • Rare; 2+ distinct tumors in same topographic area, each at least 10% of total volume, producing a single clinical and macroscopic tumor mass (Eur J Cancer B Oral Oncol 1996;32B:251)
  • Includes masses with a benign tumor component
  • Often epithelial myoepithelial carcinoma as one of the tumors
  • 0.4% of salivary gland tumors in one series (Mod Pathol 2002;15:724)
Clinical features
  • Mean age 53 - 62 years, range 28 - 81 years
  • Usually parotid gland, 0.4% parotid tumors (less than 20 cases reported), submandibular gland, palate
  • May have cervical lymph node metastases, distant metastases
  • Must sample thoroughly since only one component may be aggressive, prognosis based on most aggressive component (Arch Pathol Lab Med 1999;123:698, Eur Arch Otorhinolaryngol 2003;260:312)
Case reports
  • Surgery, radiotherapy
Microscopic (histologic) description
  • Two or more distinct tumors in same topographic area, minor component should be at least 10% of the tumor
Microscopic (histologic) images

Images hosted on other servers:

Various tumors

Cytology description
  • Features suggestive of both tumor types
Differential diagnosis
  • Biphasic tumors
  • Collision tumors: distinct masses that meet
  • Dedifferentiated tumors / tumors with high grade transformation
  • Recurrent tumor