Salivary glands
Primary salivary gland neoplasms - benign
Keratocystoma


Topic Completed: 1 September 2012

Revised: 29 April 2019

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PubMed Search: Keratocystoma

Adriana Handra-Luca, M.D.
Page views in 2018: 332
Page views in 2019 to date: 475
Cite this page: Handra-Luca A. Keratocystoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/salivaryglandskeratocystoma.html. Accessed October 22nd, 2019.
Definition / general
Clinical features
  • Very rare neoplasm of children / adults, < 20 cases reported
  • Usually parotid gland; may derive from salivary ducts undergoing squamous metaplasia
  • Excision appears to be adequate treatment
Case reports
Microscopic (histologic) description
  • Benign tumor with multicystic spaces, without lobular architecture, lined by squamous cells with focal solid epithelial nests
  • Parakeratotic and orthokeratotic keratinization without a granular layer
  • Outer layer has bud-like protrusions
  • Cells have abundant eosinophilic cytoplasm and bland, uniform nuclei
  • May have collageneous stroma, expansive growth
  • Focal foreign body reaction against keratin
  • Occasional normal mitotic figures
  • No necrosis, no invasion, no angiolymphatic invasion, no perineurial invasion, no atypia, no mucous cells
Microscopic (histologic) images

Images hosted on other servers:

37 year old man with parotid tumor

Positive stains
Differential diagnosis
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