Salivary glands
Epithelial / myoepithelial tumors

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 14 March 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Keratocystoma

Page views in 2018: 332
Page views in 2019 to date: 20
Cite this page: Handra-Luca, A. Keratocystoma. website. Accessed January 19th, 2019.
Definition / general
Clinical features
  • Very rare neoplasm of children / adults, < 20 cases reported
  • Usually parotid gland; may derive from salivary ducts undergoing squamous metaplasia
  • Excision appears to be adequate treatment
Case reports
Microscopic (histologic) description
  • Benign tumor with multicystic spaces, without lobular architecture, lined by squamous cells with focal solid epithelial nests
  • Parakeratotic and orthokeratotic keratinization without a granular layer
  • Outer layer has bud-like protrusions
  • Cells have abundant eosinophilic cytoplasm and bland, uniform nuclei
  • May have collageneous stroma, expansive growth
  • Focal foreign body reaction against keratin
  • Occasional normal mitotic figures
  • No necrosis, no invasion, no angiolymphatic invasion, no perineurial invasion, no atypia, no mucous cells
Microscopic (histologic) images

Images hosted on other servers:

37 year old man with parotid tumor

Positive stains
Differential diagnosis