Salivary glands
Kimura disease

Author: Sally Tanakchi, M.B.Ch.B. (see Authors page)
Editor: F. Zahra Aly, M.D., Ph.D.

Revised: 29 October 2015, last major update October 2015

Copyright: (c) 2002-2015,, Inc.

PubMed Search: Kimura disease [title] salivary
Definition / General
  • Rare chronic inflammatory disorder involving deep subcutaneous tissue of head and neck, often with lymphadenopathy and salivary gland involvement
  • Renal involvement has also been reported
  • Usually Asian males with elevated serum IgE and eosinophilia
  • US study showed 85% males, mean 32 years old, range 8 - 64 years (Am J Surg Pathol 2004;28:505)
  • May clinically simulate a neoplasm
  • Chronic and indolent; rarely causes death
  • Unknown infectious agent is presumed to cause an immunologic response
Case Reports
  • Surgery; may recur
Micro Description
  • Follicular hyperplasia, eosinophilic infiltrates, post-capillary venule proliferation with variable degree of fibrosis
Micro Images
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Parotid gland

Differential Diagnosis