Salivary glands
Kimura disease

Author: Sally Tanakchi (see Authors page)
Editor: F. Zahra Aly, M.D., Ph.D.

Revised: 12 March 2018, last major update October 2015

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Kimura disease salivary
Cite this page: Tanakchi, S. Kimura disease. website. Accessed April 22nd, 2018.
Definition / general
  • Rare chronic inflammatory disorder involving deep subcutaneous tissue of head and neck, often with lymphadenopathy and salivary gland involvement
  • Renal involvement has also been reported
  • Usually Asian males with elevated serum IgE and eosinophilia
  • U.S. study showed 85% males, mean 32 years old, range 8 - 64 years (Am J Surg Pathol 2004;28:505)
  • May clinically simulate a neoplasm
  • Chronic and indolent; rarely causes death
  • Unknown infectious agent is presumed to cause an immunologic response
Case reports
  • Surgery; may recur
Microscopic (histologic) description
  • Follicular hyperplasia, eosinophilic infiltrates, postcapillary venule proliferation with variable degree of fibrosis
Microscopic (histologic) images

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Parotid gland

Differential diagnosis