Salivary Gland - Kimura’s disease

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Salivary glands

Inflammation

Kimura’s disease

Reviewers: Fatima Aly, M.D., National Cancer Institute (see Reviewers page)
Revised: 7 October 2011, last major update August 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.

General
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● Rare chronic inflammatory disorder involving deep subcutaneous tissue of head and neck, often with lymphadenopathy and salivary gland involvement
● Usually Asian males with elevated serum IgE and eosinophilia
● US study showed 85% males, mean 32 years old, range 8-64 years, affects blacks, whites and Asians; rarely salivary gland involvement (Am J Surg Pathol 2004;28:505)
● May clinically simulate a neoplasm
● Chronic and indolent; rarely causes death

Treatment
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● Surgery; may recur

Micro description
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● Follicular hyperplasia, eosinophilic infiltrates, postcapillary venule proliferation

Differential diagnosis
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● Angiolymphoid hyperplasia with eosinophilia: all ethnic groups, superficial nodules, bleeding, pruritis, normal IgE and no eosinophilia

End of Salivary Glands > Inflammation > Kimura's Disease

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