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Salivary glands

Epithelial / myoepithelial tumors

Lipoadenoma


Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 27 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Slow growing tumor with glandular structures with sertoliform features and adipose tissue; oncocytic and sebaceous differentiation
● Initially described by Yau in 1997 (Mod Pathol 1997;10:242)

Clinical features
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● Usually men; affects parotid, submandibular glands
● May derive from striated duct

Case reports
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● 55 year old woman with oncocytic lipoadenoma (Int J Clin Exp Pathol 2012;5:1000)
● 64 year old man with oncocytic lipoadenoma (Pathol Res Pract 2010;206:66)
● 66 year old woman with 11 cm oncocytic tumor (Hum Pathol 1998;29:410)

Treatment
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● Complete excision

Micro description
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● Mature adipose cells (>90% mass) and proliferated glandular tissue (sharply demarcated, duct-acinar units or proliferated glands, may resemble sertoliform tubules), oncocytic change, sebaceous differentiation, squamous metaplasia

Micro images
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Various images

Cytology description
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● Adipocytic background, oncocytic cells; resembles oncocytoma, acinic cell carcinoma with oncocytic change (Acta Cytol 2009;53:437)

Stains
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● Positive for EMA, cytokeratin, CK19, CK7, CK14, CK5/6, alpha-1-antichymotrypsin (Virchows Arch 2006;449:722)
● Negative for calponin, actin
● Dual epithelial population with ductal (CK19, CK7) and basal cell (p63, CK14, CK5/6) differentiation in oncocytic areas

Molecular / cytogenetics description
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● t(12,14)/HMGA rearrangements

End of Salivary glands > Epithelial / myoepithelial tumors > Lipoadenoma


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